A synthetic cyclized antimicrobial peptide with potent effects against drug resistant skin pathogens

John Kerr White, Soumitra Mohanty, Taj Muhammad, Magdalena de Arriba Sanchez de la Campa, Wael E Houssen, Natalia Ferraz, Ulf Göransson, Annelie Brauner* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
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Dermal infections requiring treatment are usually treated with conventional
antibiotics, but the rise of bacterial resistance to first-line antibiotics warrants alternative therapeutics. Here, we report that a backbone-cyclized antimicrobial peptide, CD4-PP, designed from the human host defence peptide LL-37, has strong direct antibacterial effects on antibiotic sensitive as well as resistant type strains and clinical isolates of common skin pathogens in low (and treatment with CD4-PP is able to clear bacterial infections in infected keratinocytes.
Additionally, CD4-PP treatment significantly reduces the wound area in a lawn of
keratinocytes infected with MRSA. In conclusion, CD4-PP has the potential to serve as a future drug treating wounds infected with antibiotic resistant bacteria.
Original languageEnglish
Pages (from-to)1056-1063
Number of pages8
JournalACS Infectious Diseases
Issue number5
Early online date3 May 2023
Publication statusPublished - 12 May 2023

Bibliographical note

We would like to thank Anna Blasi-Romero for helping with the set-up of the
initial scanning electron microscopy experiments. This project was partially supported by the Stiftelsen Olle Engkvist Byggmästare (AB 186 678), Region Stockholm (AB, ALF project 995080), a fellowship grant from the EPSRC (no. EP/S027246/1, W.E.H.), the Bo Rydin Foundation (no. F30/20; NF), the Swedish Research Council (# no. 2011-3403; UG); and Postdoctoral scholarship by Elisabeth and Alfred Ahlqvists Stiftelse, Apotekarsocieteten (TM). The graphical abstract was created with a BioRender standard academic license.


  • Keratinocytes;
  • MRSA
  • synthetic antimicrobial peptide
  • LL-37
  • bactericidal peptide
  • Wound closure


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