A systematic review and dose-response meta-analysis of the effect of selenium supplementation on serum concentration of C-reactive protein

Ali Gholami; Bahareh Amirkalali; Hamid Reza Baradaran; Mitra Hariri

doi:10.1016/j.jtemb.2023.127273

A systematic review and dose-response meta-analysis of the effect of selenium supplementation on serum concentration of C-reactive protein

Ali Gholami, Bahareh Amirkalali, Hamid Reza Baradaran, Mitra Hariri^*

^*Corresponding author for this work

Applied Health Sciences

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Background: Despite conducting new studies on the potential effect of selenium in reducing inflammation; results held contradictory weights and turns into an intriguing area of research. Concerns have been raised on this matter on hand to reach conclusive/consistent results. Therefore, this study seeks to address this scientific gap by assessing randomized controlled trials (RCTs) investigating the effect of selenium intake on C-reactive protein (CRP).

Method and materials: To find all the relevant English-language RCTs, databases including SCOPUS, Web of Science, Clinical Trials.gov, PubMed, and Cochrane Library were searched with no time limit (up to June 2022). Based on the mean changes for both comparison and intervention groups, the effect sizes were calculated. Further, DerSimonian and Laird random-effects model was performed to determine the summary of overall effects and their heterogeneity.

Results: Fifteen studies were selected for systematic review and thirteen studies were known to be eligible for meta-analysis. Meta-analysis results indicated a significant effect in serum CRP concentrations compared to the control group (weighted mean difference (WMD)= −0.22 mg/L 95 % confidence interval (CI): − 0.39, − 0.04; p = 0.014).

Conclusion: In conclusion, our study confirms the downward effect of selenium on the serum concentration of CRP. On a wider level, further research is also needed to assess the selenium effect on other inflammatory mediators.

Original language	English
Article number	127273
Number of pages	11
Journal	Journal of Trace Elements in Medicine and Biology
Volume	80
Early online date	31 Jul 2023
DOIs	https://doi.org/10.1016/j.jtemb.2023.127273
Publication status	Published - Dec 2023

Bibliographical note

We are grateful to Head of Information Office and Research Network at Neyshabour University of Medical Sciences (Mrs. Taheri Shargh) for providing assistance to search databases needed for our study.

Funding
The financial support for the current study was provided by Neyshabur University of Medical Sciences, Neyshabur, Iran (No: 1401–01-325; Ethical code: IR.NUMS.REC.1401.030).

Keywords

C-reactive protein
Meta-analysis
Selenium
Systematic review

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title = "A systematic review and dose-response meta-analysis of the effect of selenium supplementation on serum concentration of C-reactive protein",

abstract = "Background: Despite conducting new studies on the potential effect of selenium in reducing inflammation; results held contradictory weights and turns into an intriguing area of research. Concerns have been raised on this matter on hand to reach conclusive/consistent results. Therefore, this study seeks to address this scientific gap by assessing randomized controlled trials (RCTs) investigating the effect of selenium intake on C-reactive protein (CRP). Method and materials: To find all the relevant English-language RCTs, databases including SCOPUS, Web of Science, Clinical Trials.gov, PubMed, and Cochrane Library were searched with no time limit (up to June 2022). Based on the mean changes for both comparison and intervention groups, the effect sizes were calculated. Further, DerSimonian and Laird random-effects model was performed to determine the summary of overall effects and their heterogeneity. Results: Fifteen studies were selected for systematic review and thirteen studies were known to be eligible for meta-analysis. Meta-analysis results indicated a significant effect in serum CRP concentrations compared to the control group (weighted mean difference (WMD)= −0.22 mg/L 95 % confidence interval (CI): − 0.39, − 0.04; p = 0.014). Conclusion: In conclusion, our study confirms the downward effect of selenium on the serum concentration of CRP. On a wider level, further research is also needed to assess the selenium effect on other inflammatory mediators.",

keywords = "C-reactive protein, Meta-analysis, Selenium, Systematic review",

author = "Ali Gholami and Bahareh Amirkalali and Baradaran, {Hamid Reza} and Mitra Hariri",

note = "We are grateful to Head of Information Office and Research Network at Neyshabour University of Medical Sciences (Mrs. Taheri Shargh) for providing assistance to search databases needed for our study. Funding The financial support for the current study was provided by Neyshabur University of Medical Sciences, Neyshabur, Iran (No: 1401–01-325; Ethical code: IR.NUMS.REC.1401.030).",

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doi = "10.1016/j.jtemb.2023.127273",

language = "English",

volume = "80",

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T1 - A systematic review and dose-response meta-analysis of the effect of selenium supplementation on serum concentration of C-reactive protein

AU - Gholami, Ali

AU - Amirkalali, Bahareh

AU - Baradaran, Hamid Reza

AU - Hariri, Mitra

N1 - We are grateful to Head of Information Office and Research Network at Neyshabour University of Medical Sciences (Mrs. Taheri Shargh) for providing assistance to search databases needed for our study. Funding The financial support for the current study was provided by Neyshabur University of Medical Sciences, Neyshabur, Iran (No: 1401–01-325; Ethical code: IR.NUMS.REC.1401.030).

PY - 2023/12

Y1 - 2023/12

N2 - Background: Despite conducting new studies on the potential effect of selenium in reducing inflammation; results held contradictory weights and turns into an intriguing area of research. Concerns have been raised on this matter on hand to reach conclusive/consistent results. Therefore, this study seeks to address this scientific gap by assessing randomized controlled trials (RCTs) investigating the effect of selenium intake on C-reactive protein (CRP). Method and materials: To find all the relevant English-language RCTs, databases including SCOPUS, Web of Science, Clinical Trials.gov, PubMed, and Cochrane Library were searched with no time limit (up to June 2022). Based on the mean changes for both comparison and intervention groups, the effect sizes were calculated. Further, DerSimonian and Laird random-effects model was performed to determine the summary of overall effects and their heterogeneity. Results: Fifteen studies were selected for systematic review and thirteen studies were known to be eligible for meta-analysis. Meta-analysis results indicated a significant effect in serum CRP concentrations compared to the control group (weighted mean difference (WMD)= −0.22 mg/L 95 % confidence interval (CI): − 0.39, − 0.04; p = 0.014). Conclusion: In conclusion, our study confirms the downward effect of selenium on the serum concentration of CRP. On a wider level, further research is also needed to assess the selenium effect on other inflammatory mediators.

AB - Background: Despite conducting new studies on the potential effect of selenium in reducing inflammation; results held contradictory weights and turns into an intriguing area of research. Concerns have been raised on this matter on hand to reach conclusive/consistent results. Therefore, this study seeks to address this scientific gap by assessing randomized controlled trials (RCTs) investigating the effect of selenium intake on C-reactive protein (CRP). Method and materials: To find all the relevant English-language RCTs, databases including SCOPUS, Web of Science, Clinical Trials.gov, PubMed, and Cochrane Library were searched with no time limit (up to June 2022). Based on the mean changes for both comparison and intervention groups, the effect sizes were calculated. Further, DerSimonian and Laird random-effects model was performed to determine the summary of overall effects and their heterogeneity. Results: Fifteen studies were selected for systematic review and thirteen studies were known to be eligible for meta-analysis. Meta-analysis results indicated a significant effect in serum CRP concentrations compared to the control group (weighted mean difference (WMD)= −0.22 mg/L 95 % confidence interval (CI): − 0.39, − 0.04; p = 0.014). Conclusion: In conclusion, our study confirms the downward effect of selenium on the serum concentration of CRP. On a wider level, further research is also needed to assess the selenium effect on other inflammatory mediators.

KW - C-reactive protein

KW - Meta-analysis

KW - Selenium

KW - Systematic review

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DO - 10.1016/j.jtemb.2023.127273

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VL - 80

JO - Journal of Trace Elements in Medicine and Biology

JF - Journal of Trace Elements in Medicine and Biology

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A systematic review and dose-response meta-analysis of the effect of selenium supplementation on serum concentration of C-reactive protein

Abstract

Bibliographical note

Keywords

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