Abstract
Red meat is considered a risk factor for colorectal cancer (CRC). Heme is considered to promote colonic hyperproliferation and cell damage. Resistant starch (RS) is a food that ferments in the colon with studies demonstrating protective effects against CRC. By utilizing the western diet model of spontaneous CRC, we determined if feeding heme (as hemin chloride) equivalent to a high red meat diet would increase colonic DNA adducts and CRC and whether RS could abrogate such effects.
| Original language | English |
|---|---|
| Pages (from-to) | 550-558 |
| Number of pages | 9 |
| Journal | Molecular Nutrition & Food Research |
| Volume | 58 |
| Issue number | 3 |
| Early online date | 1 Oct 2013 |
| DOIs | |
| Publication status | Published - Mar 2014 |
Bibliographical note
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Keywords
- heme
- 8-hydroxy-2-deoxyguanosine
- O6-Methyl-2-deoxyguanosine
- red meat
- resistant starch
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Silvia Gratz
- School of Medicine, Medical Sciences & Nutrition, The Rowett Institute of Nutrition and Health - Senior Research Fellow
Person: Academic Related - Research