Activation of γδ T Cells by Bisphosphonates

Keith Thompson, Anke J Roelofs, Marjo Jauhiainen, Hannu Mönkkönen, Jukka Mönkkönen, Michael J Rogers

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)


After decades of successful clinical use, the exact molecular mechanisms by which the anti-resorptive bisphosphonate drugs (BPs) exert their effects are now being revealed. In addition to their anti-resorptive effects, it is now apparent that nitrogen-containing BPs (N-BPs) have immunomodulatory properties. Specifically, these drugs activate immune cells called gamma, delta T lymphocytes. In this chapter we discuss the mechanism of gamma, delta T cell activation by N-BPs and propose that N-BPs may provide a safe and effective means for manipulating gamma,delta T cell activity in future immunotherapeutic approaches.
Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalAdvances in Experimental Medicine and Biology
Publication statusPublished - 2010


  • bisphosphonate
  • gamma, delta T cell
  • monocytes
  • osteoporosis
  • mevalonate pathway


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