Activation of γδ T Cells by Bisphosphonates

Keith Thompson; Anke J Roelofs; Marjo Jauhiainen; Hannu Mönkkönen; Jukka Mönkkönen; Michael J Rogers

doi:10.1007/978-1-4419-1050-9_2

Activation of γδ T Cells by Bisphosphonates

Keith Thompson, Anke J Roelofs, Marjo Jauhiainen, Hannu Mönkkönen, Jukka Mönkkönen, Michael J Rogers

Research output: Contribution to journal › Review article › peer-review

56 Citations (Scopus)

Abstract

After decades of successful clinical use, the exact molecular mechanisms by which the anti-resorptive bisphosphonate drugs (BPs) exert their effects are now being revealed. In addition to their anti-resorptive effects, it is now apparent that nitrogen-containing BPs (N-BPs) have immunomodulatory properties. Specifically, these drugs activate immune cells called gamma, delta T lymphocytes. In this chapter we discuss the mechanism of gamma, delta T cell activation by N-BPs and propose that N-BPs may provide a safe and effective means for manipulating gamma,delta T cell activity in future immunotherapeutic approaches.

Original language	English
Pages (from-to)	11-20
Number of pages	10
Journal	Advances in Experimental Medicine and Biology
Volume	658
DOIs	https://doi.org/10.1007/978-1-4419-1050-9_2
Publication status	Published - 2010

Keywords

bisphosphonate
gamma, delta T cell
monocytes
osteoporosis
mevalonate pathway

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10.1007/978-1-4419-1050-9_2

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title = "Activation of γδ T Cells by Bisphosphonates",

abstract = "After decades of successful clinical use, the exact molecular mechanisms by which the anti-resorptive bisphosphonate drugs (BPs) exert their effects are now being revealed. In addition to their anti-resorptive effects, it is now apparent that nitrogen-containing BPs (N-BPs) have immunomodulatory properties. Specifically, these drugs activate immune cells called gamma, delta T lymphocytes. In this chapter we discuss the mechanism of gamma, delta T cell activation by N-BPs and propose that N-BPs may provide a safe and effective means for manipulating gamma,delta T cell activity in future immunotherapeutic approaches.",

keywords = "bisphosphonate, gamma, delta T cell, monocytes, osteoporosis, mevalonate pathway",

author = "Keith Thompson and Roelofs, {Anke J} and Marjo Jauhiainen and Hannu M{\"o}nkk{\"o}nen and Jukka M{\"o}nkk{\"o}nen and Rogers, {Michael J}",

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T1 - Activation of γδ T Cells by Bisphosphonates

AU - Thompson, Keith

AU - Roelofs, Anke J

AU - Jauhiainen, Marjo

AU - Mönkkönen, Hannu

AU - Mönkkönen, Jukka

AU - Rogers, Michael J

PY - 2010

Y1 - 2010

N2 - After decades of successful clinical use, the exact molecular mechanisms by which the anti-resorptive bisphosphonate drugs (BPs) exert their effects are now being revealed. In addition to their anti-resorptive effects, it is now apparent that nitrogen-containing BPs (N-BPs) have immunomodulatory properties. Specifically, these drugs activate immune cells called gamma, delta T lymphocytes. In this chapter we discuss the mechanism of gamma, delta T cell activation by N-BPs and propose that N-BPs may provide a safe and effective means for manipulating gamma,delta T cell activity in future immunotherapeutic approaches.

AB - After decades of successful clinical use, the exact molecular mechanisms by which the anti-resorptive bisphosphonate drugs (BPs) exert their effects are now being revealed. In addition to their anti-resorptive effects, it is now apparent that nitrogen-containing BPs (N-BPs) have immunomodulatory properties. Specifically, these drugs activate immune cells called gamma, delta T lymphocytes. In this chapter we discuss the mechanism of gamma, delta T cell activation by N-BPs and propose that N-BPs may provide a safe and effective means for manipulating gamma,delta T cell activity in future immunotherapeutic approaches.

KW - bisphosphonate

KW - gamma, delta T cell

KW - monocytes

KW - osteoporosis

KW - mevalonate pathway

U2 - 10.1007/978-1-4419-1050-9_2

DO - 10.1007/978-1-4419-1050-9_2

M3 - Review article

C2 - 19950011

SN - 0065-2598

VL - 658

SP - 11

EP - 20

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

Activation of γδ T Cells by Bisphosphonates

Abstract

Keywords

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