Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen:  a mechanism for stimulation of fibrinolysis by platelets

K M Baeten; M C Richard; S M Kanse; Nicola Jane Mutch; J L Degen; N A Booth

doi:10.1111/j.1538-7836.2010.03813.x

Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets

K M Baeten, M C Richard, S M Kanse, Nicola Jane Mutch, J L Degen, N A Booth

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Platelets are essential for hemostasis, and they cause resistance to fibrinolysis by tissue-type plasminogen activator. In contrast, platelets enhance fibrinolysis mediated by single-chain urokinase-type plasminogen activator (scu-PA). This study investigated the mechanism behind this profibrinolytic role of platelets.

Original language	English
Pages (from-to)	1313-1322
Number of pages	10
Journal	Journal of Thrombosis and Haemostasis
Volume	8
Issue number	6
Early online date	17 Feb 2010
DOIs	https://doi.org/10.1111/j.1538-7836.2010.03813.x
Publication status	Published - Jun 2010

Keywords

Blood Platelets
Blotting, Western
Enzyme Activation
Enzyme-Linked Immunosorbent Assay
Fibrinolysis
Humans
Plasminogen
Urokinase-Type Plasminogen Activator

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abstract = "Platelets are essential for hemostasis, and they cause resistance to fibrinolysis by tissue-type plasminogen activator. In contrast, platelets enhance fibrinolysis mediated by single-chain urokinase-type plasminogen activator (scu-PA). This study investigated the mechanism behind this profibrinolytic role of platelets.",

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T1 - Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen

T2 - a mechanism for stimulation of fibrinolysis by platelets

AU - Baeten, K M

AU - Richard, M C

AU - Kanse, S M

AU - Mutch, Nicola Jane

AU - Degen, J L

AU - Booth, N A

PY - 2010/6

Y1 - 2010/6

N2 - Platelets are essential for hemostasis, and they cause resistance to fibrinolysis by tissue-type plasminogen activator. In contrast, platelets enhance fibrinolysis mediated by single-chain urokinase-type plasminogen activator (scu-PA). This study investigated the mechanism behind this profibrinolytic role of platelets.

AB - Platelets are essential for hemostasis, and they cause resistance to fibrinolysis by tissue-type plasminogen activator. In contrast, platelets enhance fibrinolysis mediated by single-chain urokinase-type plasminogen activator (scu-PA). This study investigated the mechanism behind this profibrinolytic role of platelets.

KW - Blood Platelets

KW - Blotting, Western

KW - Enzyme Activation

KW - Enzyme-Linked Immunosorbent Assay

KW - Fibrinolysis

KW - Humans

KW - Plasminogen

KW - Urokinase-Type Plasminogen Activator

U2 - 10.1111/j.1538-7836.2010.03813.x

DO - 10.1111/j.1538-7836.2010.03813.x

M3 - Article

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VL - 8

SP - 1313

EP - 1322

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

IS - 6

ER -

Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets

Abstract

Keywords

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