Age-related variation in expression of breast cancer tumour markers in Iranian patients

Fatemeh Homaei Shandiz, Fahimeh Afzaljavan, Amir Tajbakhsh, Maryam Rivadeh, Nourieh Sharifi, Mohammad Taghi Shakeri, Alireza Pasdar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: There are believed to be several risk factors affecting the prognosis of breast cancer through their effect on the growth rate of tumour. In the present study, we investigated estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), Ki-67, and tumor protein P53 (TP53) as well-known biomarkers, particularly in breast cancer prognosis, associated with age. Method: In a case-control study, 406 breast cancer patients were considered retrospectively. In order to extract the clinical and pathologic data, we employed the patients’ records. The extracted information was compared between two groups: for patients under 40 (group I) and above 40 years of age (group II). Herein, the researchers performed statistical analysis using SPSS Ver16. Results: The most prevalent type of cancer in both groups was found to be invasive ductal carcinoma. The major method of treatment was modified radical mastectomy. According to our observations, grade 3 breast cancer was more common in group I. Lymph node involvement significantly increased in group I, while oestrogen and progesterone receptor expressions were less in this group. HER2, TP53, and Ki-67 oncogenes were overexpressed in group I compared with group II. Conclusion: Expression of HER2, TP53, and Ki-67 biomarkers and a reduction in the number of hormonal receptors in younger patients (<40YO) indicated that breast cancer might be more invasive in younger women with breast cancer and therefore, they might have poorer prognosis and less favourable outcomes.

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalMiddle East Journal of Cancer
Issue number2
Publication statusPublished - 1 Apr 2021

Bibliographical note

Funding Information:
We would like to thank Mashhad University of Medical Sciences, Omid and Ghaem hospitals who supported the project.


  • Biomarkers
  • Breast cancer
  • HER2
  • Ki-67
  • TP53
  • Triple negative


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