AMP-activated protein kinase: 'a cup of tea' against cholesterol-induced neurotoxicity

Pablo Blanco Martínez de Morentin, Carmen R González, Miguel López

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Disturbances in brain cholesterol metabolism have been linked to Alzheimer's disease (AD) pathology. A high-cholesterol diet increases fibrillar amyloid β peptide (Aβ) deposition, inflammation, and apoptosis that eventually results in neurodegeneration and learning and memory impairments. In the October 2010 issue of The Journal of Pathology, Lu and colleagues provided a novel and interesting mechanism that explains how quercetin, a flavonoid found at high concentrations in green and black teas, may help to protect against cholesterol-induced neurotoxicity through activation of AMP-activated protein kinase (AMPK), a metabolic energy gauge. Further work will be necessary to address whether AMPK may be a potential target to combat neurodegenerative diseases.

Original languageEnglish
Pages (from-to)329-34
Number of pages6
JournalThe Journal of pathology
Issue number4
Early online date4 Oct 2010
Publication statusPublished - Dec 2010

Bibliographical note

This work was supported by grants from Fondo Investigaciones Sanitarias (ML: PS09/01880) and Ministerio de Ciencia e Innovación (ML: RyC-2007-00211). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII.

Research Funding
Fondo Investigaciones Sanitarias. Grant Number: ML: PS09/01880
Ministerio de Ciencia e Innovación. Grant Number: ML: RyC-2007-00211


  • AMP-Activated Protein Kinases
  • Cholesterol, Dietary
  • Enzyme Activation
  • Humans
  • Neuroprotective Agents
  • Neurotoxicity Syndromes
  • Quercetin
  • Tea


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