An Efficient Route to N-Monosubstituted Guanidino-Lactams

Sara Tommasi; Chiara Zanato; Rey Carabeo; Arduino Mangoni; Sergio Dall'Angelo; Matteo Zanda

doi:10.1055/s-0034-1378845

An Efficient Route to N-Monosubstituted Guanidino-Lactams

Sara Tommasi^*, Chiara Zanato, Rey Carabeo, Arduino Mangoni, Sergio Dall'Angelo, Matteo Zanda

^*Corresponding author for this work

National Research Council of Italy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

9 Downloads (Pure)

Abstract

A small library of guanidino-lactams were synthesized in four steps and good overall yields by following the routes: preparation of guanylating agents, synthesis of protected guanidino-acids, cyclization to fully protected guanidino-lactams, and deprotection to the target compounds. The guanidino-lactams were assayed as antimicrobials on E. coli showing no significant antibiotic activity.

Original language	English
Article number	ss-2015-n0113-op
Pages (from-to)	3067-3078
Number of pages	12
Journal	Synthesis
Volume	47
Issue number	19
Early online date	25 Jun 2015
DOIs	https://doi.org/10.1055/s-0034-1378845
Publication status	Published - Oct 2015

Keywords

guanidines
guanylation
lactams
cyclization
antimicrobials

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10.1055/s-0034-1378845Licence: Unspecified

Accepted Manuscript
© 2015 Georg Thieme Verlag KG
Accepted author manuscript, 276 KB

Cite this

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AU - Dall'Angelo, Sergio

AU - Zanda, Matteo

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An Efficient Route to N-Monosubstituted Guanidino-Lactams

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Sergio Dall'Angelo

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An Efficient Route to N-Monosubstituted Guanidino-Lactams

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Sergio Dall'Angelo

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