An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.

Anthony R Butler, Robert A. Field, Iain Robert Greig, Frederick W Flitney, Stuart K Bisland, Faisal Khan, Jill J F Belch

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.
Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalNitric Oxide: Biology and Chemistry
Issue number3
Publication statusPublished - Jun 1997
Externally publishedYes

Bibliographical note

The scanning Doppler laser imager was purchased with a grant from Tenovus. The Arthritis & Rheumatism Council and the Rollo Trust contributed to the cost of consumables


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