An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.

Anthony R Butler; Robert A. Field; Iain Robert Greig; Frederick W Flitney; Stuart K Bisland; Faisal Khan; Jill J F Belch

doi:10.1006/niox.1997.0125

An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.

Anthony R Butler, Robert A. Field, Iain Robert Greig, Frederick W Flitney, Stuart K Bisland, Faisal Khan, Jill J F Belch

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.

Original language	English
Pages (from-to)	211-217
Number of pages	7
Journal	Nitric Oxide: Biology and Chemistry
Volume	1
Issue number	3
DOIs	https://doi.org/10.1006/niox.1997.0125
Publication status	Published - Jun 1997
Externally published	Yes

Bibliographical note

Acknowledgements
The scanning Doppler laser imager was purchased with a grant from Tenovus. The Arthritis & Rheumatism Council and the Rollo Trust contributed to the cost of consumables

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10.1006/niox.1997.0125

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title = "An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.",

abstract = "A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.",

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language = "English",

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AU - Butler, Anthony R

AU - Field, Robert A.

AU - Greig, Iain Robert

AU - Flitney, Frederick W

AU - Bisland, Stuart K

AU - Khan, Faisal

AU - Belch, Jill J F

N1 - Acknowledgements The scanning Doppler laser imager was purchased with a grant from Tenovus. The Arthritis & Rheumatism Council and the Rollo Trust contributed to the cost of consumables

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Y1 - 1997/6

N2 - A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.

AB - A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.

UR - https://doi.org/10.1006/niox.1997.0125

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DO - 10.1006/niox.1997.0125

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JO - Nitric Oxide: Biology and Chemistry

JF - Nitric Oxide: Biology and Chemistry

IS - 3

ER -

An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.

Abstract

Bibliographical note

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