An imbalance in serum concentrations of inflammatory and anti-inflammatory cytokines in hypertension

Seyed Reza Mirhafeza, Mohsen Mohebati, Mahboobeh Feiz Disfani, Maryam Saberi Karimian, Mahmoud Ebrahimi, Amir Avan, Saied Eslami, Alireza Pasdar, Hassan Rooki, Habibollah Esmaeili, Gordon A. Ferns, Majid Ghayour-Mobarhan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)


Hypertension is an important risk factor for cardiovascular disease and there is increasing evidence that inflammation and abnormal immune responses are involved in the pathogenesis of hypertension. However, the data on the association between specific cytokine concentrations and hypertension are inconsistent. We have evaluated the association between 12 cytokines/growth factors and the presence of different degrees of hypertension, comparing these concentrations to values in a healthy group of subjects. The concentrations of interleukin (IL)-1α,-1β,-2,-4,-6,-8,-10, tumor necrosis factor (TNF-α), interferong (IFN-γ), monocyte chemoattractant protein (MCP-1), epidermal growth factor, and vascular endothelial growth factor were measured in 155 hypertensive patients and 148 healthy subjects, using EV-3513 cytokine biochip arrays, a competitive chemiluminescence immunoassay. Univariate and multivariate analyses were used to evaluate the association of specific cytokines and growth factors with systolic blood pressure (SBP) and diastolic blood pressure (DBP). Hypertensive subjects had higher serum concentrations of IL-1α,-2,-8, vascular endothelial growth factor, IFN-γ, TNF-α, MCP-1, and epidermal growth factor; and lower concentrations of anti-inflammatory cytokine, IL-10 (P <.05), compared with the healthy individuals. The serum concentrations of IL-4,-6, and-1b did not differ between the hypertensive subjects and control group. Univariate and multivariate analyses revealed that IL-1a and IFN-γ were independent predictors of a high SBP, while IFN-γ, IL-1α, TNF-α, and MCP-1 remained statistically significant for DBP after correction for age, gender, Body mass index, smoking, fasting blood glucose, and triglycerides. There was a significant association between the concentrations of several cytokines and hypertension. These associations may either be related to common underlying factors that cause hypertension and may also be proinflammatory or because these inflammatory cytokines might directly be involved in the etiology of hypertension.

Original languageEnglish
Pages (from-to)614-623
Number of pages10
JournalJournal of the American Society of Hypertension
Issue number9
Publication statusPublished - 2014

Bibliographical note

Funding: This work was supported by Research Project No. 910823, as a PhD thesis, financed by the cardiovascular research center, Mashhad University of Medical Sciences.


  • Blood pressure
  • Growth factors
  • Inflammation


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