Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry

Ghislaine Scelo; Carlos A.  Torres-Duque; Jorge F Maspero; Trung N Tran; Ruth B Murray; Neil  Martin; Andrew Menzies-Gow; Mark Hew; Matthew J Peters; Peter G.  Gibson; George C Christoff; Todor A Popov; Andréanne Côté; Celine Bergeron; Delbert Dorscheid; J. Mark FitzGerald; Kenneth R. Chapman; Louis Philippe  Boulet; Mohit  Bhutani; Mohsen Sadatsafavi; Libardo  Jiménez-Maldonado; Mauricio  Duran-Silva; Bellanid  Rodriguez; Carlos Andres  Celis-Preciado; Diana Jimena  Cano-Rosales; Ivan  Solarte; Maria Jose  Fernandez-Sanchez; Patricia  Parada-Tovar; Anna  von Bülow; Anne Sofie Bjerrum; Charlotte  Suppli Ulrik; Karin Dahl  Assing; Karin Dahl  Assing; Susanne Hansen; Alan Altraja; Arnaud Bourdin; Camille  Taillé; Jeremy  Charriot; Nicolas Roche; Andriana I. Papaioannou; Konstantinos  Kostikas; Nikolaos G Papadopoulos; Sundeep Salvi; Deirdre  Long; Patrick Mitchell; Richard W  Costello; Concetta  Sirena; Cristina  Cardini; Enrico Heffler; Francesca Puggioni; Giorgio Walter Canonica; Giuseppe  Guida; Takashi Iwanaga; Mona Al-Ahmad; Désirée Larenas-Linnemann; Ulises  García; Piotr Kuna; João A. Fonseca; Riyad  Al-Lehebi; Mariko Siyue Koh; Chin Kook Rhee; Borja G. Cosio; Luis Perez de Llano; Diahn-Warng Perng Steve; Erick  Wan-Chun Huang; Hao-Chien  Wang; MingJu  Tsai; Bassam Mahboub; Laila Ibraheem Jaber  Salameh; David Jackson; John Busby; Liam G Heaney; Paul E Pfeffer; Amanda Grippen  Goddard; Eileen Wang; Flavia  Hoyte; Michael E Wechsler; Nicholas  Chapman; Rohit  Katial; Victoria Carter; Lakmini Bulathsinhala; Neva Eleangovan; Cono  Ariti; Juntao  Lyu; David Price; Celeste Porsbjerg

doi:10.1016/j.anai.2023.08.021

Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry

Ghislaine Scelo, Carlos A. Torres-Duque, Jorge F Maspero, Trung N Tran, Ruth B Murray, Neil Martin, Andrew Menzies-Gow, Mark Hew, Matthew J Peters, Peter G. Gibson, George C Christoff, Todor A Popov, Andréanne Côté, Celine Bergeron , Delbert Dorscheid, J. Mark FitzGerald, Kenneth R. Chapman, Louis Philippe Boulet, Mohit Bhutani, Mohsen SadatsafaviLibardo Jiménez-Maldonado, Mauricio Duran-Silva, Bellanid Rodriguez, Carlos Andres Celis-Preciado, Diana Jimena Cano-Rosales, Ivan Solarte, Maria Jose Fernandez-Sanchez, Patricia Parada-Tovar, Anna von Bülow, Anne Sofie Bjerrum, Charlotte Suppli Ulrik, Karin Dahl Assing, Karin Dahl Assing, Susanne Hansen, Alan Altraja, Arnaud Bourdin, Camille Taillé, Jeremy Charriot, Nicolas Roche, Andriana I. Papaioannou, Konstantinos Kostikas, Nikolaos G Papadopoulos, Sundeep Salvi, Deirdre Long, Patrick Mitchell, Richard W Costello, Concetta Sirena, Cristina Cardini, Enrico Heffler, Francesca Puggioni, Giorgio Walter Canonica, Giuseppe Guida, Takashi Iwanaga, Mona Al-Ahmad, Désirée Larenas-Linnemann, Ulises García, Piotr Kuna, João A. Fonseca, Riyad Al-Lehebi, Mariko Siyue Koh, Chin Kook Rhee, Borja G. Cosio, Luis Perez de Llano, Diahn-Warng Perng Steve, Erick Wan-Chun Huang, Hao-Chien Wang, MingJu Tsai, Bassam Mahboub, Laila Ibraheem Jaber Salameh, David Jackson, John Busby, Liam G Heaney, Paul E Pfeffer, Amanda Grippen Goddard, Eileen Wang, Flavia Hoyte, Michael E Wechsler, Nicholas Chapman, Rohit Katial, Victoria Carter, Lakmini Bulathsinhala, Neva Eleangovan, Cono Ariti, Juntao Lyu, David Price^* (Corresponding Author), Celeste Porsbjerg

^*Corresponding author for this work

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Abstract

Background: Investigation for the presence of asthma comorbidities is recommended by GINA as their presence can complicate asthma management.
Objective: To understand the prevalence and pattern of comorbidities and multimorbidity in adults with severe asthma and their association with asthma-related outcomes. Methods: This was a cross-sectional study using data from the International Severe Asthma Registry from 22 countries. Thirty comorbidities were identified and categorized a priori as either (1) potentially T2-related, (2) potentially oral corticosteroid (OCS)-related or (3) mimicking/aggravating asthma. The association between comorbidities and asthma-related outcomes was investigated using multivariable models adjusted for country, age at enrollment, and sex.
Results: Of 11,821 patients, 69%, 67%, and 55% had ≥1 potentially T2-related, potentially OCSrelated, or mimicking/aggravating comorbidities, respectively; 57% had ≥3 comorbidities, and 33% had comorbidities in all three categories. Patients with allergic rhinitis (AR), nasal polyposis (NP), and chronic rhinosinusitis (CRS) experienced 1.12- (p=0.003), 1.16- (p(ORs: 1.37-1.57). Greater number of comorbidities was associated with worse outcome.
Conclusion: In a global study, comorbidity or multimorbidity is reported in most adults with severe asthma and is associated with poorer asthma-related outcomes.

Original language	English
Pages (from-to)	42-53
Number of pages	12
Journal	Annals of Allergy, Asthma, and Immunology
Volume	132
Issue number	1
Early online date	18 Dec 2023
DOIs	https://doi.org/10.1016/j.anai.2023.08.021
Publication status	Published - 1 Jan 2024

Bibliographical note

Funding Source: This study was conducted by the Observational and Pragmatic Research Institute (OPRI) Pte Ltd and was partially funded by Optimum Patient Care Global and AstraZeneca Ltd. No funding was received by the Observational & Pragmatic Research Institute Pte Ltd (OPRI) for its contribution.
Acknowledgements: The authors acknowledge Mr. Joash Tan (BSc, Hons), of the Observational and Pragmatic Research Institute (OPRI), and Ms Andrea Lim (BSc, Hons) of the Observational Pragmatic Research Institute (OPRI) for their editorial and formatting assistance that supported the development of this manuscript.

Data Availability Statement

Supplementary data: Supplementary material associated with this article can be found in the online version at doi:10.1016/j.anai.2023.08.021.

Keywords

Allergic rhinitis
anxiety/depression
chronic obstructive pulmonary disease
chronic rhinosinusitis
diabetes, dyslipidemia
gastroesophageal reflux disease
hypertension
nasal polys
Obesity
osteoporosis
sleep apnea

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Scelo_etal_AAAI_Analysis_Of_Comorbidities_VoR
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Final published version, 1.02 MBLicence: CC BY-NC-ND

Cite this

Scelo, G., Torres-Duque, C. A., Maspero, J. F., Tran, T. N., Murray, R. B., Martin, N., Menzies-Gow, A., Hew, M., Peters, M. J., Gibson, P. G., Christoff, G. C., Popov, T. A., Côté, A., Bergeron , C., Dorscheid, D., FitzGerald, J. M., Chapman, K. R., Boulet, L. P., Bhutani, M., ... Porsbjerg, C. (2024). Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry. Annals of Allergy, Asthma, and Immunology, 132(1), 42-53. https://doi.org/10.1016/j.anai.2023.08.021

Scelo, G, Torres-Duque, CA, Maspero, JF, Tran, TN, Murray, RB, Martin, N, Menzies-Gow, A, Hew, M, Peters, MJ, Gibson, PG, Christoff, GC, Popov, TA, Côté, A, Bergeron , C, Dorscheid, D, FitzGerald, JM, Chapman, KR, Boulet, LP, Bhutani, M, Sadatsafavi, M, Jiménez-Maldonado, L, Duran-Silva, M, Rodriguez, B, Celis-Preciado, CA, Cano-Rosales, DJ, Solarte, I, Fernandez-Sanchez, MJ, Parada-Tovar, P, von Bülow, A, Bjerrum, AS, Suppli Ulrik, C, Assing, KD, Assing, KD, Hansen, S, Altraja, A, Bourdin, A, Taillé, C, Charriot, J, Roche, N, Papaioannou, AI, Kostikas, K, Papadopoulos, NG, Salvi, S, Long, D, Mitchell, P, Costello, RW, Sirena, C, Cardini, C, Heffler, E, Puggioni, F, Canonica, GW, Guida, G, Iwanaga, T, Al-Ahmad, M, Larenas-Linnemann, D, García, U, Kuna, P, Fonseca, JA, Al-Lehebi, R, Koh, MS, Rhee, CK, Cosio, BG, Perez de Llano, L, Perng Steve, D-W, Wan-Chun Huang, E, Wang, H-C, Tsai, M, Mahboub, B, Salameh, LIJ, Jackson, D, Busby, J, Heaney, LG, Pfeffer, PE, Goddard, AG, Wang, E, Hoyte, F, Wechsler, ME, Chapman, N, Katial, R, Carter, V, Bulathsinhala, L, Eleangovan, N, Ariti, C, Lyu, J, Price, D & Porsbjerg, C 2024, 'Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry', Annals of Allergy, Asthma, and Immunology, vol. 132, no. 1, pp. 42-53. https://doi.org/10.1016/j.anai.2023.08.021

@article{423be674bbad4a56a9d03c299ae29ce8,

title = "Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry",

abstract = "Background: Investigation for the presence of asthma comorbidities is recommended by GINA as their presence can complicate asthma management.Objective: To understand the prevalence and pattern of comorbidities and multimorbidity in adults with severe asthma and their association with asthma-related outcomes. Methods: This was a cross-sectional study using data from the International Severe Asthma Registry from 22 countries. Thirty comorbidities were identified and categorized a priori as either (1) potentially T2-related, (2) potentially oral corticosteroid (OCS)-related or (3) mimicking/aggravating asthma. The association between comorbidities and asthma-related outcomes was investigated using multivariable models adjusted for country, age at enrollment, and sex.Results: Of 11,821 patients, 69%, 67%, and 55% had ≥1 potentially T2-related, potentially OCSrelated, or mimicking/aggravating comorbidities, respectively; 57% had ≥3 comorbidities, and 33% had comorbidities in all three categories. Patients with allergic rhinitis (AR), nasal polyposis (NP), and chronic rhinosinusitis (CRS) experienced 1.12- (p=0.003), 1.16- (p(ORs: 1.37-1.57). Greater number of comorbidities was associated with worse outcome.Conclusion: In a global study, comorbidity or multimorbidity is reported in most adults with severe asthma and is associated with poorer asthma-related outcomes.",

keywords = "Allergic rhinitis, anxiety/depression, chronic obstructive pulmonary disease, chronic rhinosinusitis, diabetes, dyslipidemia, gastroesophageal reflux disease, hypertension, nasal polys, Obesity, osteoporosis, sleep apnea",

author = "Ghislaine Scelo and Torres-Duque, {Carlos A.} and Maspero, {Jorge F} and Tran, {Trung N} and Murray, {Ruth B} and Neil Martin and Andrew Menzies-Gow and Mark Hew and Peters, {Matthew J} and Gibson, {Peter G.} and Christoff, {George C} and Popov, {Todor A} and Andr{\'e}anne C{\^o}t{\'e} and Celine Bergeron and Delbert Dorscheid and FitzGerald, {J. Mark} and Chapman, {Kenneth R.} and Boulet, {Louis Philippe} and Mohit Bhutani and Mohsen Sadatsafavi and Libardo Jim{\'e}nez-Maldonado and Mauricio Duran-Silva and Bellanid Rodriguez and Celis-Preciado, {Carlos Andres} and Cano-Rosales, {Diana Jimena} and Ivan Solarte and Fernandez-Sanchez, {Maria Jose} and Patricia Parada-Tovar and {von B{\"u}low}, Anna and Bjerrum, {Anne Sofie} and {Suppli Ulrik}, Charlotte and Assing, {Karin Dahl} and Assing, {Karin Dahl} and Susanne Hansen and Alan Altraja and Arnaud Bourdin and Camille Taill{\'e} and Jeremy Charriot and Nicolas Roche and Papaioannou, {Andriana I.} and Konstantinos Kostikas and Papadopoulos, {Nikolaos G} and Sundeep Salvi and Deirdre Long and Patrick Mitchell and Costello, {Richard W} and Concetta Sirena and Cristina Cardini and Enrico Heffler and Francesca Puggioni and Canonica, {Giorgio Walter} and Giuseppe Guida and Takashi Iwanaga and Mona Al-Ahmad and D{\'e}sir{\'e}e Larenas-Linnemann and Ulises Garc{\'i}a and Piotr Kuna and Fonseca, {Jo{\~a}o A.} and Riyad Al-Lehebi and Koh, {Mariko Siyue} and Rhee, {Chin Kook} and Cosio, {Borja G.} and {Perez de Llano}, Luis and {Perng Steve}, Diahn-Warng and {Wan-Chun Huang}, Erick and Hao-Chien Wang and MingJu Tsai and Bassam Mahboub and Salameh, {Laila Ibraheem Jaber} and David Jackson and John Busby and Heaney, {Liam G} and Pfeffer, {Paul E} and Goddard, {Amanda Grippen} and Eileen Wang and Flavia Hoyte and Wechsler, {Michael E} and Nicholas Chapman and Rohit Katial and Victoria Carter and Lakmini Bulathsinhala and Neva Eleangovan and Cono Ariti and Juntao Lyu and David Price and Celeste Porsbjerg",

note = "Funding Source: This study was conducted by the Observational and Pragmatic Research Institute (OPRI) Pte Ltd and was partially funded by Optimum Patient Care Global and AstraZeneca Ltd. No funding was received by the Observational & Pragmatic Research Institute Pte Ltd (OPRI) for its contribution. Acknowledgements: The authors acknowledge Mr. Joash Tan (BSc, Hons), of the Observational and Pragmatic Research Institute (OPRI), and Ms Andrea Lim (BSc, Hons) of the Observational Pragmatic Research Institute (OPRI) for their editorial and formatting assistance that supported the development of this manuscript. ",

year = "2024",

month = jan,

day = "1",

doi = "10.1016/j.anai.2023.08.021",

language = "English",

volume = "132",

pages = "42--53",

journal = "Annals of Allergy, Asthma, and Immunology",

issn = "1081-1206",

publisher = "Elsevier",

number = "1",

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TY - JOUR

T1 - Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry

AU - Scelo, Ghislaine

AU - Torres-Duque, Carlos A.

AU - Maspero, Jorge F

AU - Tran, Trung N

AU - Murray, Ruth B

AU - Martin, Neil

AU - Menzies-Gow, Andrew

AU - Hew, Mark

AU - Peters, Matthew J

AU - Gibson, Peter G.

AU - Christoff, George C

AU - Popov, Todor A

AU - Côté, Andréanne

AU - Bergeron , Celine

AU - Dorscheid, Delbert

AU - FitzGerald, J. Mark

AU - Chapman, Kenneth R.

AU - Boulet, Louis Philippe

AU - Bhutani, Mohit

AU - Sadatsafavi, Mohsen

AU - Jiménez-Maldonado, Libardo

AU - Duran-Silva, Mauricio

AU - Rodriguez, Bellanid

AU - Celis-Preciado, Carlos Andres

AU - Cano-Rosales, Diana Jimena

AU - Solarte, Ivan

AU - Fernandez-Sanchez, Maria Jose

AU - Parada-Tovar, Patricia

AU - von Bülow, Anna

AU - Bjerrum, Anne Sofie

AU - Suppli Ulrik, Charlotte

AU - Assing, Karin Dahl

AU - Hansen, Susanne

AU - Altraja, Alan

AU - Bourdin, Arnaud

AU - Taillé, Camille

AU - Charriot, Jeremy

AU - Roche, Nicolas

AU - Papaioannou, Andriana I.

AU - Kostikas, Konstantinos

AU - Papadopoulos, Nikolaos G

AU - Salvi, Sundeep

AU - Long, Deirdre

AU - Mitchell, Patrick

AU - Costello, Richard W

AU - Sirena, Concetta

AU - Cardini, Cristina

AU - Heffler, Enrico

AU - Puggioni, Francesca

AU - Canonica, Giorgio Walter

AU - Guida, Giuseppe

AU - Iwanaga, Takashi

AU - Al-Ahmad, Mona

AU - Larenas-Linnemann, Désirée

AU - García, Ulises

AU - Kuna, Piotr

AU - Fonseca, João A.

AU - Al-Lehebi, Riyad

AU - Koh, Mariko Siyue

AU - Rhee, Chin Kook

AU - Cosio, Borja G.

AU - Perez de Llano, Luis

AU - Perng Steve, Diahn-Warng

AU - Wan-Chun Huang, Erick

AU - Wang, Hao-Chien

AU - Tsai, MingJu

AU - Mahboub, Bassam

AU - Salameh, Laila Ibraheem Jaber

AU - Jackson, David

AU - Busby, John

AU - Heaney, Liam G

AU - Pfeffer, Paul E

AU - Goddard, Amanda Grippen

AU - Wang, Eileen

AU - Hoyte, Flavia

AU - Wechsler, Michael E

AU - Chapman, Nicholas

AU - Katial, Rohit

AU - Carter, Victoria

AU - Bulathsinhala, Lakmini

AU - Eleangovan, Neva

AU - Ariti, Cono

AU - Lyu, Juntao

AU - Price, David

AU - Porsbjerg, Celeste

N1 - Funding Source: This study was conducted by the Observational and Pragmatic Research Institute (OPRI) Pte Ltd and was partially funded by Optimum Patient Care Global and AstraZeneca Ltd. No funding was received by the Observational & Pragmatic Research Institute Pte Ltd (OPRI) for its contribution. Acknowledgements: The authors acknowledge Mr. Joash Tan (BSc, Hons), of the Observational and Pragmatic Research Institute (OPRI), and Ms Andrea Lim (BSc, Hons) of the Observational Pragmatic Research Institute (OPRI) for their editorial and formatting assistance that supported the development of this manuscript.

PY - 2024/1/1

Y1 - 2024/1/1

N2 - Background: Investigation for the presence of asthma comorbidities is recommended by GINA as their presence can complicate asthma management.Objective: To understand the prevalence and pattern of comorbidities and multimorbidity in adults with severe asthma and their association with asthma-related outcomes. Methods: This was a cross-sectional study using data from the International Severe Asthma Registry from 22 countries. Thirty comorbidities were identified and categorized a priori as either (1) potentially T2-related, (2) potentially oral corticosteroid (OCS)-related or (3) mimicking/aggravating asthma. The association between comorbidities and asthma-related outcomes was investigated using multivariable models adjusted for country, age at enrollment, and sex.Results: Of 11,821 patients, 69%, 67%, and 55% had ≥1 potentially T2-related, potentially OCSrelated, or mimicking/aggravating comorbidities, respectively; 57% had ≥3 comorbidities, and 33% had comorbidities in all three categories. Patients with allergic rhinitis (AR), nasal polyposis (NP), and chronic rhinosinusitis (CRS) experienced 1.12- (p=0.003), 1.16- (p(ORs: 1.37-1.57). Greater number of comorbidities was associated with worse outcome.Conclusion: In a global study, comorbidity or multimorbidity is reported in most adults with severe asthma and is associated with poorer asthma-related outcomes.

AB - Background: Investigation for the presence of asthma comorbidities is recommended by GINA as their presence can complicate asthma management.Objective: To understand the prevalence and pattern of comorbidities and multimorbidity in adults with severe asthma and their association with asthma-related outcomes. Methods: This was a cross-sectional study using data from the International Severe Asthma Registry from 22 countries. Thirty comorbidities were identified and categorized a priori as either (1) potentially T2-related, (2) potentially oral corticosteroid (OCS)-related or (3) mimicking/aggravating asthma. The association between comorbidities and asthma-related outcomes was investigated using multivariable models adjusted for country, age at enrollment, and sex.Results: Of 11,821 patients, 69%, 67%, and 55% had ≥1 potentially T2-related, potentially OCSrelated, or mimicking/aggravating comorbidities, respectively; 57% had ≥3 comorbidities, and 33% had comorbidities in all three categories. Patients with allergic rhinitis (AR), nasal polyposis (NP), and chronic rhinosinusitis (CRS) experienced 1.12- (p=0.003), 1.16- (p(ORs: 1.37-1.57). Greater number of comorbidities was associated with worse outcome.Conclusion: In a global study, comorbidity or multimorbidity is reported in most adults with severe asthma and is associated with poorer asthma-related outcomes.

KW - Allergic rhinitis

KW - anxiety/depression

KW - chronic obstructive pulmonary disease

KW - chronic rhinosinusitis

KW - diabetes, dyslipidemia

KW - gastroesophageal reflux disease

KW - hypertension

KW - nasal polys

KW - Obesity

KW - osteoporosis

KW - sleep apnea

U2 - 10.1016/j.anai.2023.08.021

DO - 10.1016/j.anai.2023.08.021

M3 - Article

C2 - 37640263

SN - 1081-1206

VL - 132

SP - 42

EP - 53

JO - Annals of Allergy, Asthma, and Immunology

JF - Annals of Allergy, Asthma, and Immunology

IS - 1

ER -

Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry

Abstract

Bibliographical note

Data Availability Statement

Keywords

UN SDGs

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