Androgen receptor

Iain J. McEwan, Lee B. Smith

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


The majority of physiological actions of testosterone and dihydrotestosterone are mediated by the androgen receptor, a member of the nuclear receptor superfamily, encoded as a single gene on the X-chromosome. Androgen receptor has four functional domains, N-terminal, DNA binding, hinge and ligand binding. In response to hormone binding the androgen receptor protein positively or negatively regulates gene expression (classical pathway) or signaling cascade activity (nonclassical pathway) in target tissues. Androgen receptor is long known to be essential for correct masculinization, and male fertility, however recent studies have identified novel influences androgen receptor plays in both lifelong health, and disease.

Original languageEnglish
Title of host publicationEncyclopedia of Reproduction
Number of pages5
ISBN (Electronic)9780128151457
Publication statusPublished - 30 Jul 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc. All rights reserved.


  • Amino-terminal domain
  • Androgen response element
  • CAIS
  • Coactivators
  • Dihydrotestosterone
  • DNA binding domain
  • Gene expression
  • Hsp 90
  • Ligand binding domain
  • Testicular feminization
  • Testosterone


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