Anesthetics disrupt brain development via actions on the mTOR pathway

Jing Xu, Eunchai Kang, C David Mintz* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)
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Experiments conducted in non-human primates have recently provided new evidence supporting a longstanding concern that exposure to general anesthesia during late intrauterine life or early childhood can cause lasting cognitive deficits through harmful effects on brain development. The mammalian target of rapamycin (mTOR) signaling system plays a key role in both normal brain development and in a wide range of developmental disorders that are characterized by cognitive deficits. Intriguingly, our recently published work shows that anesthetics can chronically alter mTOR signaling in the hippocampal dentate gyrus and that normalization of mTOR signaling can prevent anesthesia-induced perturbation of structure and function. In this addendum, we briefly discuss the putative role of mTOR in developmental anesthetic neurotoxicity.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalCommunicative and Integrative Biology
Issue number2
Early online date9 Apr 2018
Publication statusPublished - 2018

Bibliographical note

This work was supported by an ACCM StAAR Award and NIH 1R01GM120519-01 to C.D.M, NARSAD to E.K., a grant from the Chinese Scholarship Council to J.X.


  • mTOR
  • cell signalling
  • anesthesia
  • neurogenesis
  • neurotoxicity


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