Animal models of airway inflammation and airway smooth muscle remodelling in asthma

Judith E Allen, Robert J Bischof, Herng-Yu Sucie Chang, Jeremy A Hirota, Stuart J Hirst, Mark D Inman, Wayne Mitzner, Tara Sutherland

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23 Citations (Scopus)


Asthma is a complex disease that involves chronic inflammation and subsequent decline in airway function. The widespread use of animal models has greatly contributed to our understanding of the cellular and molecular pathways underlying human allergic asthma. Animal models of allergic asthma include smaller animal models which offer 'ease of use' and availability of reagents, and larger animal models that may be used to address aspects of allergic airways disease not possible in humans or smaller animal models. This review examines the application and suitability of various animal models for studying mechanisms of airway inflammation and tissue remodelling in allergic asthma, with a specific focus on airway smooth muscle.
Original languageEnglish
Pages (from-to)455-465
Number of pages11
JournalPharmacology & Therapeutics
Issue number5
Early online date23 Apr 2009
Publication statusPublished - 1 Oct 2009

Bibliographical note

Judith Allen was supported by the Medical Research Council UK and Asthma UK. Robert Bischof was supported by the National Health and Medical Research Council (NHMRC) of Australia (310603) and Allergenix Pty Ltd. Herng-Yu Chang was supported by NIH grants HL-10342 and HL-07534. Jeremy Hirota was funded by a Canadian Lung Association/Canadian Thoracic Society Studentship. Jeremy Hirota and Mark Inman were also supported by the Canadian Institutes for Health Research (MOP-36328) and Astra-Zeneca. Stuart Hirst acknowledges the support of the NHMRC (566904) and Asthma UK (05/022, 05/027, 07/034). Wayne Mitzner was supported by NIH grants HL-10342 and HL-07534. Tara Sutherland was supported by Asthma UK. The authors would also like to thank Astra-Zeneca for sponsoring and the travel grants to attend the Sixth International Young Investigators' Symposium on Smooth Muscle in Sydney, Australia, November 2007.


  • Animals
  • Asthma
  • Disease Models
  • Animal
  • Gonadal Steroid Hormones
  • Humans
  • Immune System
  • Inflammation
  • Inflammation Mediators
  • Muscle
  • Smooth
  • Respiratory System
  • Sex Characteristics


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