Anti-VP6 IgG antibodies against group A and group C rotaviruses in South India

I Mukhopadhya; D Anbu; M Iturriza-Gomara; J J Gray; D W Brown; O Kavanagh; M K Estes; G Kang

doi:10.1017/S0950268809990732

Anti-VP6 IgG antibodies against group A and group C rotaviruses in South India

I Mukhopadhya, D Anbu, M Iturriza-Gomara, J J Gray, D W Brown, O Kavanagh, M K Estes, G Kang

Christian Medical College and Hospital,

Research output: Contribution to journal › Article › peer-review

Abstract

In an epidemiological survey from South India, 936 serum samples were tested for IgG against recombinant baculovirus-expressed VP6 proteins from human group A and group C rotaviruses. The overall seroprevalence for group A was 100% and for group C was 25.32% (95% CI 22.64-28.21). The lowest seroprevalence for group C was in children aged <10 years (16.79%). An age-related rise in seroprevalence in group C, but not group A, suggests different patterns of exposure. Seroprevalence was similar in rural and urban subjects, unlike the higher prevalence in rural subjects in studies elsewhere.

Original language	English
Pages (from-to)	442-7
Number of pages	6
Journal	Epidemiology and Infection
Volume	138
Issue number	3
DOIs	https://doi.org/10.1017/S0950268809990732
Publication status	Published - Mar 2010
Externally published	Yes

Keywords

Adolescent
Adult
Antigens, Viral/immunology
Capsid Proteins/immunology
Child
Child, Preschool
Humans
Immunoglobulin G/blood
India/epidemiology
Infant
Rotavirus/classification
Rotavirus Infections/epidemiology
Seroepidemiologic Studies
Young Adult

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10.1017/S0950268809990732

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title = "Anti-VP6 IgG antibodies against group A and group C rotaviruses in South India",

abstract = "In an epidemiological survey from South India, 936 serum samples were tested for IgG against recombinant baculovirus-expressed VP6 proteins from human group A and group C rotaviruses. The overall seroprevalence for group A was 100% and for group C was 25.32% (95% CI 22.64-28.21). The lowest seroprevalence for group C was in children aged <10 years (16.79%). An age-related rise in seroprevalence in group C, but not group A, suggests different patterns of exposure. Seroprevalence was similar in rural and urban subjects, unlike the higher prevalence in rural subjects in studies elsewhere.",

keywords = "Adolescent, Adult, Antigens, Viral/immunology, Capsid Proteins/immunology, Child, Child, Preschool, Humans, Immunoglobulin G/blood, India/epidemiology, Infant, Rotavirus/classification, Rotavirus Infections/epidemiology, Seroepidemiologic Studies, Young Adult",

author = "I Mukhopadhya and D Anbu and M Iturriza-Gomara and Gray, {J J} and Brown, {D W} and O Kavanagh and Estes, {M K} and G Kang",

year = "2010",

month = mar,

doi = "10.1017/S0950268809990732",

language = "English",

volume = "138",

pages = "442--7",

journal = "Epidemiology and Infection",

issn = "0950-2688",

publisher = "Cambridge University Press",

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TY - JOUR

T1 - Anti-VP6 IgG antibodies against group A and group C rotaviruses in South India

AU - Mukhopadhya, I

AU - Anbu, D

AU - Iturriza-Gomara, M

AU - Gray, J J

AU - Brown, D W

AU - Kavanagh, O

AU - Estes, M K

AU - Kang, G

PY - 2010/3

Y1 - 2010/3

N2 - In an epidemiological survey from South India, 936 serum samples were tested for IgG against recombinant baculovirus-expressed VP6 proteins from human group A and group C rotaviruses. The overall seroprevalence for group A was 100% and for group C was 25.32% (95% CI 22.64-28.21). The lowest seroprevalence for group C was in children aged <10 years (16.79%). An age-related rise in seroprevalence in group C, but not group A, suggests different patterns of exposure. Seroprevalence was similar in rural and urban subjects, unlike the higher prevalence in rural subjects in studies elsewhere.

AB - In an epidemiological survey from South India, 936 serum samples were tested for IgG against recombinant baculovirus-expressed VP6 proteins from human group A and group C rotaviruses. The overall seroprevalence for group A was 100% and for group C was 25.32% (95% CI 22.64-28.21). The lowest seroprevalence for group C was in children aged <10 years (16.79%). An age-related rise in seroprevalence in group C, but not group A, suggests different patterns of exposure. Seroprevalence was similar in rural and urban subjects, unlike the higher prevalence in rural subjects in studies elsewhere.

KW - Adolescent

KW - Adult

KW - Antigens, Viral/immunology

KW - Capsid Proteins/immunology

KW - Child

KW - Child, Preschool

KW - Humans

KW - Immunoglobulin G/blood

KW - India/epidemiology

KW - Infant

KW - Rotavirus/classification

KW - Rotavirus Infections/epidemiology

KW - Seroepidemiologic Studies

KW - Young Adult

U2 - 10.1017/S0950268809990732

DO - 10.1017/S0950268809990732

M3 - Article

C2 - 19723364

SN - 0950-2688

VL - 138

SP - 442

EP - 447

JO - Epidemiology and Infection

JF - Epidemiology and Infection

IS - 3

ER -

Anti-VP6 IgG antibodies against group A and group C rotaviruses in South India

Abstract

Keywords

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