Abstract
Objectives
This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:
Primary objective
To assess whether anticholinergic burden, as defined at the level of each individual scale, is a prognostic factor for further cognitive decline or neuropsychiatric disturbances in people with mild cognitive impairment (MCI) or dementia.
Secondary objective
To compare the prognostic validity of different anticholinergic burden scales.
To examine the effect of type of dementia and severity of dementia on the association between anticholinergic burden and rate of cognitive decline or neuropsychiatric disturbances.
To examine the effect of setting (care home versus non‐care home) on the association between anticholinergic burden and rate of cognitive decline or neuropsychiatric disturbances.
To examine whether anticholinergic burden is a prognostic factor for other clinical outcomes in people with MCI or dementia
This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:
Primary objective
To assess whether anticholinergic burden, as defined at the level of each individual scale, is a prognostic factor for further cognitive decline or neuropsychiatric disturbances in people with mild cognitive impairment (MCI) or dementia.
Secondary objective
To compare the prognostic validity of different anticholinergic burden scales.
To examine the effect of type of dementia and severity of dementia on the association between anticholinergic burden and rate of cognitive decline or neuropsychiatric disturbances.
To examine the effect of setting (care home versus non‐care home) on the association between anticholinergic burden and rate of cognitive decline or neuropsychiatric disturbances.
To examine whether anticholinergic burden is a prognostic factor for other clinical outcomes in people with MCI or dementia
| Original language | English |
|---|---|
| Article number | CD015196 |
| Number of pages | 19 |
| Journal | Cochrane Database of Systematic Reviews |
| Volume | 2021 |
| Issue number | 11 |
| Early online date | 24 Jun 2022 |
| DOIs | |
| Publication status | Published - 22 Aug 2022 |
Bibliographical note
AcknowledgementsWe would like to thank Dr Kate Wang, Dr Andrew Stafford, Ms Catherine Hofstetter, and Dr Joanna Damen for their helpful peer review comments on this protocol.