TY - JOUR
T1 - Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats
AU - Khorrami, Mohammad Bagher
AU - Sadeghnia, Hamid Reza
AU - Pasdar, Alireza
AU - Ghayour-Mobarhan, Majid
AU - Riahi-Zanjani, Bamdad
AU - Hashemzadeh, Alireza
AU - Zare, Mohammad
AU - Darroudi, Majid
N1 - Funding Information:
We would like to thank the Vice Chancellery for Research and Technology, MUMS for financial support (grant no 930954) and facilities.
PY - 2019/4/26
Y1 - 2019/4/26
N2 - Purpose: The purpose of this study was to investigate the acute toxic potential of cerium oxide nanoparticles (CNPs) synthesized by pullulan in adult male Wistar rats. Patients and methods: Thirty male Wistar rats randomly were divided into five experimental groups of six animals each. The animals were received 50, 100, 200, and 400 mg/kg CNPs for 14 consecutive days. At the end of the experiment, the rats were euthanized and histopathological evaluation of the liver and renal tissues, as well ass, the markers of serum oxidative stress including thiobarbituric acid reactive substances, total sulfhydryl content, and antioxidant capacity (using ferric reducing/antioxidant power assay) were assessed. Hematological parameters and the activity of liver function enzymes were also measured. Results: The results of this study showed that CNPs caused no significant changes in the activity of liver enzymes, hepatic and renal histopathology and hematological parameters, while significantly improved serum redox status. Conclusion: Acute administration of pullulan-mediated CNPs is safe and possess antioxidant activity.
AB - Purpose: The purpose of this study was to investigate the acute toxic potential of cerium oxide nanoparticles (CNPs) synthesized by pullulan in adult male Wistar rats. Patients and methods: Thirty male Wistar rats randomly were divided into five experimental groups of six animals each. The animals were received 50, 100, 200, and 400 mg/kg CNPs for 14 consecutive days. At the end of the experiment, the rats were euthanized and histopathological evaluation of the liver and renal tissues, as well ass, the markers of serum oxidative stress including thiobarbituric acid reactive substances, total sulfhydryl content, and antioxidant capacity (using ferric reducing/antioxidant power assay) were assessed. Hematological parameters and the activity of liver function enzymes were also measured. Results: The results of this study showed that CNPs caused no significant changes in the activity of liver enzymes, hepatic and renal histopathology and hematological parameters, while significantly improved serum redox status. Conclusion: Acute administration of pullulan-mediated CNPs is safe and possess antioxidant activity.
KW - Green synthesis
KW - Metal oxide
KW - Radical scavenger
KW - Sol-gel
KW - Toxicology
UR - http://www.scopus.com/inward/record.url?scp=85065574307&partnerID=8YFLogxK
U2 - 10.2147/IJN.S194192
DO - 10.2147/IJN.S194192
M3 - Article
C2 - 31114200
AN - SCOPUS:85065574307
SN - 1176-9114
VL - 14
SP - 2915
EP - 2926
JO - International Journal of Nanomedicine
JF - International Journal of Nanomedicine
ER -