Antioxidant phenylacetic acid derivatives from the seeds of Ilex aquifolium

Lutfun Nahar, Wendy Roslyn Russell, M Middleton, M Sheob, Satya Sarker

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Reversed-phase preparative HPLC analysis of the methanol extract of the seeds of Ilex aquifolium afforded two antioxidant phenylacetic acid derivatives, 2,4-dihydroxyphenylacetic acid (1) and 2,4-dihydroxyphenylacetic acid methyl ester (2). The structures were determined by spectroscopic methods. In the DPPH assay for antioxidant activity, the IC50 values of 1 and 2 were 1.50 x 10-3 and 2.55 x 10-3 mg mL-1, respectively, compared to 2.88 x 10-5 mg mL-1 of quercetin, a natural antioxidant.
Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalActa Pharmaceutica
Issue number2
Publication statusPublished - Jun 2005


  • Ilex aquifolium (Aquifoliaceae)
  • phenylacetic acid derivatives
  • antioxidant
  • DPPH


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