Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria

Oluwatofunmilayo A. Diyaolu* (Corresponding Author), Gagan Preet, Adeshola A. Fagbemi, F Annang, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Olusoji O. Adebisi, Emmanuel Tope Oluwabusola, Bruce F. Milne, Marcel Jaspars, Rainer Ebel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
5 Downloads (Pure)

Abstract

In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC50 values of 9.6 µM and 2.3 µM, respectively, while 2 displayed IC50 values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds.
Original languageEnglish
Article number109
Number of pages16
JournalAntibiotics
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2023

Bibliographical note

This article belongs to the Special Issue Antimicrobial and Anti-infective Activity of Natural Products.

The authors are grateful to the Schlumberger Foundation Faculty for the Future board for their financial support in conducting the present study.

Data Availability Statement

Not applicable.

Keywords

  • aspergillus fumigatus
  • OSMAC
  • Metabolomics
  • molecular docking
  • antitrypanosomal
  • antiplasmodial
  • insilico molecular docking

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