Abstract
Marrubium globosum ssp. libanoticum is a medicinal plant used in Lebanon to reduce pain and smooth muscle spasms. A chloroform extract obtained from M. globosum aerial parts reduced acetylcholine-induced contractions in the isolated mouse ileum. The purification of this extract identified, among 12 isolated labdane diterpenoids, four new compounds, named 13-epicyllenin A (4), 13,15-diepicyllenin A (5), marrulibacetal (9), and marrulactone (11). Their structures were determined by spectroscopic methods. Compound 9, which exerted antispasmodic activity, is likely the active ingredient of the extract. Preliminary structure-activity relationships for this class of compounds are suggested.
Original language | English |
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Pages (from-to) | 1477-1481 |
Number of pages | 5 |
Journal | Journal of Natural Products |
Volume | 72 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2009 |
Keywords
- Acetylcholine
- Animals
- Diterpenes
- Ileum
- Lebanon
- Male
- Marrubium
- Mice
- Molecular Structure
- Muscle, Smooth
- Parasympatholytics
- Plant Extracts
- Plants, Medicinal
- Structure-Activity Relationship
- Journal Article