Abstract
In metazoans, accurate replication of chromosomes is ensured by the coupling of DNA synthesis to the synthesis of histone proteins. Expression of replication-dependent histone genes is restricted to S-phase by a combination of cell cycle-regulated transcriptional and post-transcriptional control mechanisms and is linked to DNA replication by a poorly understood mechanism involving checkpoint kinases [Su, Gao, Schneider, Helt, Weiss, O'Reilly, Bohmann and Zhao (2004) EMBO J. 23, 1133–1143; Kaygun and Marzluff (2005) Nat. Struct. Mol. Biol. 12, 794–800]. Here we propose a model for the molecular mechanisms that link these two important processes within S-phase, and propose roles for multiple checkpoints in this mechanism.
Original language | English |
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Pages (from-to) | 1369-1371 |
Number of pages | 3 |
Journal | Biochemical Society Transactions |
Volume | 35 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2007 |
Keywords
- ataxia-telangiectasia mutated gene (ATM)
- ataxia-telangiectasia and Rad3-related (ATR)
- DNA-activated protein kinase
- DNA replication
- histone gene expression
- human phosphatidylinositol 3-kinase-related kinase
- RNA stability