Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.
Bibliographical noteWe thank the College of Physical Sciences, University of Aberdeen, for provision of infrastructure and facilities in the Marine Biodiscovery Centre. This work was supported financially by the Biotechnological and Biological Sciences Research Council under the RCUK-CONICYT Newton International Research Project (JIC: CA586) and the Basal Programme of CONICYT for funding of the Centre for Biotechnology and Bioengineering, CeBiB (project FB0001).
- Journal Article
- Asenjonamides A–C
- Streptomyces asenjonii
- Atacama Desert