@inbook{df94822c96cd414bb7cb7a6c4edc2fb1,
title = "Assays for the Screening and Characterization of Tau Aggregation Inhibitors",
abstract = "Aggregation of tau protein is a pathological hallmark of Alzheimer's disease and other neurodegenerative tauopathies. Inhibition of tau aggregation may provide a method for treatment of these disorders. Methods to identify tau aggregation inhibitors (TAIs) in vitro are useful and here we describe assays for TAIs using purified recombinant tau protein fragments in a cell-free immunoassay format and in a stably transfected cell model to create a more physiological environment.",
keywords = "Humans, tau Proteins/metabolism, Alzheimer Disease/drug therapy, Tauopathies/drug therapy, Immunoassay, Biological Assay",
author = "David Horsley and Rickard, {Janet E} and Thomas Vorley and Leeper, {Matilda F} and Wischik, {Claude M} and Harrington, {Charles R}",
year = "2024",
month = mar,
day = "24",
doi = "10.1007/978-1-0716-3629-9_5",
language = "English",
isbn = "978-1-0716-3628-2",
volume = "2754",
series = "Methods in molecular biology (Clifton, N.J.)",
publisher = "Humana Press",
pages = "93--104",
booktitle = "Tau Protein",
edition = "2",
}