TY - JOUR
T1 - Assessment of the role of gut health in childhood stunting in a multisite, longitudinal study in India, Indonesia and Senegal
T2 - A UKRI GCRF Action Against Stunting Hub protocol
AU - Momo Kadia, Benjamin
AU - Ramsteijn, Anouschka S.
AU - Dasi, Teena
AU - Fahmida, Umi
AU - Kulkarni, Bharati
AU - Faye, Babacar
AU - Htet, Min Kyaw
AU - Sow, Doudou
AU - Kalashikam, Rajender Rao
AU - Sharma, Ritu
AU - Sudibya, Arienta R.P.
AU - Kusuma, Sari
AU - Angelin, Tiffany C.
AU - Nurfadilah, Mifa
AU - Jobarteh, Modou Lamin
AU - Diop, Ndeye Sokhna
AU - Gabain, Isobel
AU - Calvo-Urbano, Beatriz
AU - Ferguson, Elaine
AU - Haggarty, Paul
AU - Heffernan, Claire
AU - Webster, Joanne P.
AU - Walker, Alan W.
AU - Allen, Stephen
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.
PY - 2024/2/27
Y1 - 2024/2/27
N2 - Introduction Childhood stunting has a complex aetiology, with poor gut health being an important contributor. This study will assess inter-relationships between maternal and infant gut health indices and infant linear growth. Inter-relationships between gut health indices, systemic inflammation and growth hormones in early childhood will also be assessed. Methods and analysis A longitudinal observational study of cohorts of 600 newborns and their mothers in India, Indonesia and Senegal will be conducted. Women will be recruited during pregnancy and their children followed up to age 24 months. Stool, urine and blood samples will be collected from the women and children for assessments of helminthic and protozoal parasites, bacterial pathogens, faecal microbiota taxa, biomarkers of environmental enteric dysfunction, systemic inflammation and growth hormones. Child anthropometric measurements will be collected at birth and at ages 3, 6, 9, 12, 18 and 24 months. The gut health indices will be integrated with cohort data from other Action Against Stunting Hub (AASH) workstreams for interdisciplinary analyses of childhood stunting and the development of a new typology of stunting. Discussion This study will advance scientific understanding of the role of gut health in childhood stunting and will contribute to a broader knowledge of the complex aetiology of this condition as part of the interdisciplinary AASH research to reduce the global burden of childhood stunting. Ethics and dissemination This study has been approved by the relevant Ethics Committees in Senegal, India, and Indonesia and LSHTM. The results will be submitted for publication in peer-reviewed journals.
AB - Introduction Childhood stunting has a complex aetiology, with poor gut health being an important contributor. This study will assess inter-relationships between maternal and infant gut health indices and infant linear growth. Inter-relationships between gut health indices, systemic inflammation and growth hormones in early childhood will also be assessed. Methods and analysis A longitudinal observational study of cohorts of 600 newborns and their mothers in India, Indonesia and Senegal will be conducted. Women will be recruited during pregnancy and their children followed up to age 24 months. Stool, urine and blood samples will be collected from the women and children for assessments of helminthic and protozoal parasites, bacterial pathogens, faecal microbiota taxa, biomarkers of environmental enteric dysfunction, systemic inflammation and growth hormones. Child anthropometric measurements will be collected at birth and at ages 3, 6, 9, 12, 18 and 24 months. The gut health indices will be integrated with cohort data from other Action Against Stunting Hub (AASH) workstreams for interdisciplinary analyses of childhood stunting and the development of a new typology of stunting. Discussion This study will advance scientific understanding of the role of gut health in childhood stunting and will contribute to a broader knowledge of the complex aetiology of this condition as part of the interdisciplinary AASH research to reduce the global burden of childhood stunting. Ethics and dissemination This study has been approved by the relevant Ethics Committees in Senegal, India, and Indonesia and LSHTM. The results will be submitted for publication in peer-reviewed journals.
KW - gastroenterology
KW - growth
KW - microbiology
KW - molecular biology
KW - parasitology
UR - http://www.scopus.com/inward/record.url?scp=85186395769&partnerID=8YFLogxK
U2 - 10.1136/bmjpo-2022-001637
DO - 10.1136/bmjpo-2022-001637
M3 - Article
C2 - 38417928
AN - SCOPUS:85186395769
SN - 2399-9772
VL - 8
JO - BMJ Paediatrics Open
JF - BMJ Paediatrics Open
IS - Suppl 1
M1 - e001637
ER -