Assessment of the Teratogenic Effect of Drugs on the Chicken Embryo

Lucas Rosa Fraga* (Corresponding Author), Maikel Rosa de Oliveira, Karina Maria Wermann, Neil Vargesson

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pre-clinical trials are an essential step that underpins the drug discovery, development and safety process. During this process, animal testing is performed to determine the safety of new compounds and any potential adverse effects. Developmental toxicity tests are carried out to verify whether the drug has potential to cause congenital anomalies to the developing embryo/foetus. Chicken embryos are very useful for these purposes and present several advantages, such as low cost of production and housing, easy handling and manipulation, rapid development in addition to sharing similarities to the human embryo at molecular, cellular, and anatomical levels. In this chapter, we bring methods for using the chicken embryo model for testing the teratogenic effects of drugs and assessing the main outcomes of them.
Original languageEnglish
Title of host publicationTeratogenicity Testing
Subtitle of host publicationMethods and Protocols
PublisherSpringer
Chapter12
Pages251-260
Number of pages10
Volume2753
Edition2
ISBN (Electronic)978-1-0716-3625-1
ISBN (Print)978-1-0716-3624-4
DOIs
Publication statusPublished - 30 Jan 2024

Publication series

NameMethods in Molecular Biology
PublisherHumana NY
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Bibliographical note

Acknowledgements
Fraga’s Lab is funded by Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundo de Incentivo à Pesquisa e Eventos (FIPE) of the Hospital de Clínicas de Porto Alegre (HCPA). The authors thank to Universidade Federal do Rio Grande do Sul (UFRGS) and HCPA.

Keywords

  • Developmental toxicity
  • Animal model
  • Drug development
  • Congenital anomalies
  • Cartilage staining
  • Morphology

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