Abstract
Introduction: Chronic pain represents a global health problem with a considerable economic burden. The relation of alcohol intake and chronic pain conditions was assessed in several studies with conflicting results. We used dose–response meta-analysis techniques to answer the question of whether alcohol intake is related to chronic pain occurrence.
Methods: We searched MEDLINE, Embase, and other databases to identify cohort and case-control studies on alcohol consumption and chronic pain. Sixteen studies were eligible with a total population of 642 587 individuals. Fixed-effects and random-effects pooled estimates were obtained by weighting log odds ratios (ORs) in case-control studies and log incidence rate ratios in cohort studies by the inverse of their variance. A heterogeneity assessment and a dose–response analysis were carried out. Quality scoring was also performed.
Results: Our results show that any alcohol consumption was related to lower odds of chronic pain (pooled OR=0.76; 95% confidence interval [CI], 0.61–0.95). The association was non-linear. The ORs by quartile of alcohol doses were as follows: OR2nd quartile=0.74; 95% CI, 0.64–0.87; OR3rd quartile=0.67; 95% CI, 0.53–0.86; and OR4th quartile=0.75; 95% CI, 0.50–1.14. This association was observed for cohort studies (OR=0.77; 95% CI, 0.61–0.98) and European studies (OR=0.65; 95% CI, 0.48–0.87) only. Studies with complete adjustment for confounding factors showed a stronger relation than those with incomplete adjustment (OR=0.69; 95% CI, 0.48–0.99 and OR=0.85; 95% CI, 0.65–1.11, respectively).
Conclusion: Alcohol consumption presents a non-linear inverse association with the occurrence of chronic pain. Although plausible mechanisms could explain this protective effect, other explanations, including reverse causation, are probable.
Original language | English |
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Pages (from-to) | 355-365 |
Number of pages | 11 |
Journal | British Journal of Anaesthesia |
Volume | 129 |
Issue number | 3 |
Early online date | 19 Aug 2022 |
DOIs | |
Publication status | Published - 1 Sept 2022 |
Bibliographical note
Funding Information:Regional Ministry of Education, Universities and Vocational Training (Consellería de Cultura, Educación y Ordenación Universitaria. Xunta de Galicia), Santiago de Compostela, Spain (ED431C 2018/20 to BT's work in meta-analysis).
Data Availability Statement
Supplementary data to this article can be found online at https://doi.org/10.1016/j.bja.2022.03.010Keywords
- alcohol
- chronic pain
- dose–response
- drinking
- meta-analysis