Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta-analysis of case-control studies

Sogand Sodagar; Yekta Ghane; Amirhossein Heidari; Nazila Heidari; Elaheh Khodadust; Seyyed Amir Yasin Ahmadi; Farnoosh Seirafianpour; Hamid Baradaran; Azadeh Goodarzi

doi:10.1002/hsr2.1576

Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta-analysis of case-control studies

Sogand Sodagar, Yekta Ghane, Amirhossein Heidari, Nazila Heidari, Elaheh Khodadust, Seyyed Amir Yasin Ahmadi, Farnoosh Seirafianpour, Hamid Baradaran, Azadeh Goodarzi

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

BACKGROUND AND AIM: Metabolic syndrome (MetS) is a well-known noncommunicable disease that plays a significant role in emerging other chronic disorders and following complications. MetS is also involved in the pathophysiology of numerous dermatological diseases. We aim to evaluate the association of MetS with the most prevalent dermatological diseases.

METHODS: A systematic search was carried out on PubMed, Science Direct, Web of Science, Cochrane, as well as the Google Scholar search engine. Only English case-control studies regarding MetS and any skin disease from the beginning of 2010 up to November 15, 2022, were selected. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA).

RESULTS: A total of 37 studies (13,830 participants) met the inclusion criteria. According to our result, patients with psoriasis, hidradenitis suppurativa (HS), vitiligo, androgenetic alopecia (AGA), and lichen planus (LP) have a higher chance of having MetS compared to the general population. Furthermore, people with seborrheic dermatitis (SED) and rosacea are more prone to insulin resistance, high blood pressure (BP), and higher blood lipids. After pooling data, the meta-analysis revealed a significant association between MetS and skin diseases (pooled odds ratio [OR]: 3.28, 95% confidence interval: 2.62-4.10). Concerning the type of disease, MetS has been correlated with AGA (OR: 11.86), HS (OR: 4.46), LP (OR: 3.79), and SED (OR: 2.45). Psoriasis also showed a significant association but with high heterogeneity (OR: 2.89). Moreover, skin diseases and MetS are strongly associated in Spain (OR: 5.25) and Thailand (OR: 11.86). Regarding the metaregression model, the effect size was reduced with increasing age (OR: 0.965), while the size increased with AGA (OR: 3.064).

CONCLUSIONS: MetS is closely associated with skin complications. Dermatologists and other multidisciplinary teams should be cautious while treating these patients to prevent severe complications resulting from MetS.

Original language	English
Article number	e1576
Journal	Health Science Reports
Volume	6
Issue number	9
DOIs	https://doi.org/10.1002/hsr2.1576
Publication status	Published - 25 Sept 2023

Bibliographical note

ACKNOWLEDGMENTSThe authors would like to express their gratitude to the authorities ofRasool Akram Medical Complex Clinical Research DevelopmentCenter (RCRDC) for their technical and editorial assistance.

Data Availability Statement

All data produced in the present study are available upon reasonablerequest to the authors.

Keywords

androgenic alopecia
dermatology
hidradenitis suppurativa
insulin resistance
lichen planus
metabolic syndrome
psoriasis
rosacea
seborrheic dermatitis
skin disease
vitiligo

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Sodagar_HSR_Association_Between_Metabolic_VOR
© 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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Cite this

@article{99155cb3f5b94cf4b7ad15bf883e04f3,

title = "Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta-analysis of case-control studies",

abstract = "BACKGROUND AND AIM: Metabolic syndrome (MetS) is a well-known noncommunicable disease that plays a significant role in emerging other chronic disorders and following complications. MetS is also involved in the pathophysiology of numerous dermatological diseases. We aim to evaluate the association of MetS with the most prevalent dermatological diseases.METHODS: A systematic search was carried out on PubMed, Science Direct, Web of Science, Cochrane, as well as the Google Scholar search engine. Only English case-control studies regarding MetS and any skin disease from the beginning of 2010 up to November 15, 2022, were selected. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA).RESULTS: A total of 37 studies (13,830 participants) met the inclusion criteria. According to our result, patients with psoriasis, hidradenitis suppurativa (HS), vitiligo, androgenetic alopecia (AGA), and lichen planus (LP) have a higher chance of having MetS compared to the general population. Furthermore, people with seborrheic dermatitis (SED) and rosacea are more prone to insulin resistance, high blood pressure (BP), and higher blood lipids. After pooling data, the meta-analysis revealed a significant association between MetS and skin diseases (pooled odds ratio [OR]: 3.28, 95% confidence interval: 2.62-4.10). Concerning the type of disease, MetS has been correlated with AGA (OR: 11.86), HS (OR: 4.46), LP (OR: 3.79), and SED (OR: 2.45). Psoriasis also showed a significant association but with high heterogeneity (OR: 2.89). Moreover, skin diseases and MetS are strongly associated in Spain (OR: 5.25) and Thailand (OR: 11.86). Regarding the metaregression model, the effect size was reduced with increasing age (OR: 0.965), while the size increased with AGA (OR: 3.064).CONCLUSIONS: MetS is closely associated with skin complications. Dermatologists and other multidisciplinary teams should be cautious while treating these patients to prevent severe complications resulting from MetS.",

keywords = "androgenic alopecia, dermatology, hidradenitis suppurativa, insulin resistance, lichen planus, metabolic syndrome, psoriasis, rosacea, seborrheic dermatitis, skin disease, vitiligo",

author = "Sogand Sodagar and Yekta Ghane and Amirhossein Heidari and Nazila Heidari and Elaheh Khodadust and Ahmadi, {Seyyed Amir Yasin} and Farnoosh Seirafianpour and Hamid Baradaran and Azadeh Goodarzi",

note = "ACKNOWLEDGMENTSThe authors would like to express their gratitude to the authorities ofRasool Akram Medical Complex Clinical Research DevelopmentCenter (RCRDC) for their technical and editorial assistance.",

year = "2023",

month = sep,

day = "25",

doi = "10.1002/hsr2.1576",

language = "English",

volume = "6",

journal = "Health Science Reports",

issn = "2398-8835",

publisher = "Wiley",

number = "9",

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TY - JOUR

T1 - Association between metabolic syndrome and prevalent skin diseases

T2 - A systematic review and meta-analysis of case-control studies

AU - Sodagar, Sogand

AU - Ghane, Yekta

AU - Heidari, Amirhossein

AU - Heidari, Nazila

AU - Khodadust, Elaheh

AU - Ahmadi, Seyyed Amir Yasin

AU - Seirafianpour, Farnoosh

AU - Baradaran, Hamid

AU - Goodarzi, Azadeh

N1 - ACKNOWLEDGMENTSThe authors would like to express their gratitude to the authorities ofRasool Akram Medical Complex Clinical Research DevelopmentCenter (RCRDC) for their technical and editorial assistance.

PY - 2023/9/25

Y1 - 2023/9/25

N2 - BACKGROUND AND AIM: Metabolic syndrome (MetS) is a well-known noncommunicable disease that plays a significant role in emerging other chronic disorders and following complications. MetS is also involved in the pathophysiology of numerous dermatological diseases. We aim to evaluate the association of MetS with the most prevalent dermatological diseases.METHODS: A systematic search was carried out on PubMed, Science Direct, Web of Science, Cochrane, as well as the Google Scholar search engine. Only English case-control studies regarding MetS and any skin disease from the beginning of 2010 up to November 15, 2022, were selected. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA).RESULTS: A total of 37 studies (13,830 participants) met the inclusion criteria. According to our result, patients with psoriasis, hidradenitis suppurativa (HS), vitiligo, androgenetic alopecia (AGA), and lichen planus (LP) have a higher chance of having MetS compared to the general population. Furthermore, people with seborrheic dermatitis (SED) and rosacea are more prone to insulin resistance, high blood pressure (BP), and higher blood lipids. After pooling data, the meta-analysis revealed a significant association between MetS and skin diseases (pooled odds ratio [OR]: 3.28, 95% confidence interval: 2.62-4.10). Concerning the type of disease, MetS has been correlated with AGA (OR: 11.86), HS (OR: 4.46), LP (OR: 3.79), and SED (OR: 2.45). Psoriasis also showed a significant association but with high heterogeneity (OR: 2.89). Moreover, skin diseases and MetS are strongly associated in Spain (OR: 5.25) and Thailand (OR: 11.86). Regarding the metaregression model, the effect size was reduced with increasing age (OR: 0.965), while the size increased with AGA (OR: 3.064).CONCLUSIONS: MetS is closely associated with skin complications. Dermatologists and other multidisciplinary teams should be cautious while treating these patients to prevent severe complications resulting from MetS.

AB - BACKGROUND AND AIM: Metabolic syndrome (MetS) is a well-known noncommunicable disease that plays a significant role in emerging other chronic disorders and following complications. MetS is also involved in the pathophysiology of numerous dermatological diseases. We aim to evaluate the association of MetS with the most prevalent dermatological diseases.METHODS: A systematic search was carried out on PubMed, Science Direct, Web of Science, Cochrane, as well as the Google Scholar search engine. Only English case-control studies regarding MetS and any skin disease from the beginning of 2010 up to November 15, 2022, were selected. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA).RESULTS: A total of 37 studies (13,830 participants) met the inclusion criteria. According to our result, patients with psoriasis, hidradenitis suppurativa (HS), vitiligo, androgenetic alopecia (AGA), and lichen planus (LP) have a higher chance of having MetS compared to the general population. Furthermore, people with seborrheic dermatitis (SED) and rosacea are more prone to insulin resistance, high blood pressure (BP), and higher blood lipids. After pooling data, the meta-analysis revealed a significant association between MetS and skin diseases (pooled odds ratio [OR]: 3.28, 95% confidence interval: 2.62-4.10). Concerning the type of disease, MetS has been correlated with AGA (OR: 11.86), HS (OR: 4.46), LP (OR: 3.79), and SED (OR: 2.45). Psoriasis also showed a significant association but with high heterogeneity (OR: 2.89). Moreover, skin diseases and MetS are strongly associated in Spain (OR: 5.25) and Thailand (OR: 11.86). Regarding the metaregression model, the effect size was reduced with increasing age (OR: 0.965), while the size increased with AGA (OR: 3.064).CONCLUSIONS: MetS is closely associated with skin complications. Dermatologists and other multidisciplinary teams should be cautious while treating these patients to prevent severe complications resulting from MetS.

KW - androgenic alopecia

KW - dermatology

KW - hidradenitis suppurativa

KW - insulin resistance

KW - lichen planus

KW - metabolic syndrome

KW - psoriasis

KW - rosacea

KW - seborrheic dermatitis

KW - skin disease

KW - vitiligo

U2 - 10.1002/hsr2.1576

DO - 10.1002/hsr2.1576

M3 - Article

C2 - 37752973

SN - 2398-8835

VL - 6

JO - Health Science Reports

JF - Health Science Reports

IS - 9

M1 - e1576

ER -

Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta-analysis of case-control studies

Abstract

Bibliographical note

Data Availability Statement

Keywords

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