Association between the rs2241883 polymorphism of the fatty acid-binding protein-1 (FABP1) gene and obesity in a population of MASHAD study cohort

Mohsen Valizadeh; Malihe Aghasizadeh; Fatemeh Shaghi; Ali Moradi; Haleh S.T. Afshari; Reza Zare-Feyzabadi; Maryam Saberi-Karimian; Mohammad Hashemi; Fatemeh N.S. Doust; Mohsen Nematy; Ensieh A. Bahre; Seyed H. Aghaei-Bakhtiari; Hamideh Ghazizadeh; Hamideh Safarian-Bana; Niloofar Shabani; Habibollah Esmaily; Gordon A. Ferns; Alireza Pasdar; Majid Ghayour-Mobarhan

doi:10.1002/mgg3.2173

Association between the rs2241883 polymorphism of the fatty acid-binding protein-1 (FABP1) gene and obesity in a population of MASHAD study cohort

Mohsen Valizadeh, Malihe Aghasizadeh, Fatemeh Shaghi, Ali Moradi, Haleh S.T. Afshari, Reza Zare-Feyzabadi, Maryam Saberi-Karimian, Mohammad Hashemi, Fatemeh N.S. Doust, Mohsen Nematy, Ensieh A. Bahre, Seyed H. Aghaei-Bakhtiari, Hamideh Ghazizadeh, Hamideh Safarian-Bana, Niloofar Shabani, Habibollah Esmaily, Gordon A. Ferns, Alireza Pasdar^*, Majid Ghayour-Mobarhan^*

^*Corresponding author for this work

Applied Medicine

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Abstract

BACKGROUND AND AIMS: The fatty acid-binding proteins (FABPs) gene polymorphisms are related to several metabolic properties. We investigated the association of SNPs rs2241883 of FABP 1 gene with obesity to evaluate the role of FABP1 gene in the pathogenesis of obesity in the population of MASHAD study cohort.

METHODS: In this cross-sectional study, 2731 individuals (1883 Obese and 848 nonobese) aged 35 to 65 years old, were enrolled from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study cohort. DNA Quantitation was determined using the NanoDrop®-1000 instrument (NanoDrop-Technologies). The rs2241883 polymorphisms were genotyped by double ARMs PCR (double amplification refractory mutation system) reactions. Data analysis was carried out using SPSS 22 and a p < 0.05 was set for statistical significance.

RESULTS: The results showed that after adjusting for confounding factors, subjects having the CC genotype for rs2241883 polymorphism were at a higher risk of BMI ≥ 30 mg/kg 2 with OR of 1.79 (CI = 1.05-3.07; p = 0.03) and 1.76 (CI = 1.04-2.99; p = 0.04) comparing with reference group using codominant and dominant models, respectively.

CONCLUSION: The results showed that CC genotype for rs2241883 polymorphism is related to an increased risk of the obesity in dominant and codominant models in a population of MASHAD study cohort.

Original language	English
Article number	e2173
Number of pages	8
Journal	Molecular Genetics and Genomic Medicine
Volume	11
Issue number	7
Early online date	7 Apr 2023
DOIs	https://doi.org/10.1002/mgg3.2173
Publication status	Published - Jul 2023

Bibliographical note

Funding Information:
We would like to thank Mashhad University of Medical Sciences Research Council for their financial supports.

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable
request

Keywords

ARMs PCR
atherosclerosis
FABPs
genotype
metabolic syndrome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2023 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.
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Valizadeh, M., Aghasizadeh, M., Shaghi, F., Moradi, A., Afshari, H. S. T., Zare-Feyzabadi, R., Saberi-Karimian, M., Hashemi, M., Doust, F. N. S., Nematy, M., Bahre, E. A., Aghaei-Bakhtiari, S. H., Ghazizadeh, H., Safarian-Bana, H., Shabani, N., Esmaily, H., Ferns, G. A., Pasdar, A., & Ghayour-Mobarhan, M. (2023). Association between the rs2241883 polymorphism of the fatty acid-binding protein-1 (FABP1) gene and obesity in a population of MASHAD study cohort. Molecular Genetics and Genomic Medicine, 11(7), Article e2173. https://doi.org/10.1002/mgg3.2173

Valizadeh, M, Aghasizadeh, M, Shaghi, F, Moradi, A, Afshari, HST, Zare-Feyzabadi, R, Saberi-Karimian, M, Hashemi, M, Doust, FNS, Nematy, M, Bahre, EA, Aghaei-Bakhtiari, SH, Ghazizadeh, H, Safarian-Bana, H, Shabani, N, Esmaily, H, Ferns, GA, Pasdar, A & Ghayour-Mobarhan, M 2023, 'Association between the rs2241883 polymorphism of the fatty acid-binding protein-1 (FABP1) gene and obesity in a population of MASHAD study cohort', Molecular Genetics and Genomic Medicine, vol. 11, no. 7, e2173. https://doi.org/10.1002/mgg3.2173

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title = "Association between the rs2241883 polymorphism of the fatty acid-binding protein-1 (FABP1) gene and obesity in a population of MASHAD study cohort",

abstract = "BACKGROUND AND AIMS: The fatty acid-binding proteins (FABPs) gene polymorphisms are related to several metabolic properties. We investigated the association of SNPs rs2241883 of FABP 1 gene with obesity to evaluate the role of FABP1 gene in the pathogenesis of obesity in the population of MASHAD study cohort.METHODS: In this cross-sectional study, 2731 individuals (1883 Obese and 848 nonobese) aged 35 to 65 years old, were enrolled from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study cohort. DNA Quantitation was determined using the NanoDrop{\textregistered}-1000 instrument (NanoDrop-Technologies). The rs2241883 polymorphisms were genotyped by double ARMs PCR (double amplification refractory mutation system) reactions. Data analysis was carried out using SPSS 22 and a p < 0.05 was set for statistical significance.RESULTS: The results showed that after adjusting for confounding factors, subjects having the CC genotype for rs2241883 polymorphism were at a higher risk of BMI ≥ 30 mg/kg 2 with OR of 1.79 (CI = 1.05-3.07; p = 0.03) and 1.76 (CI = 1.04-2.99; p = 0.04) comparing with reference group using codominant and dominant models, respectively. CONCLUSION: The results showed that CC genotype for rs2241883 polymorphism is related to an increased risk of the obesity in dominant and codominant models in a population of MASHAD study cohort.",

keywords = "ARMs PCR, atherosclerosis, FABPs, genotype, metabolic syndrome",

author = "Mohsen Valizadeh and Malihe Aghasizadeh and Fatemeh Shaghi and Ali Moradi and Afshari, {Haleh S.T.} and Reza Zare-Feyzabadi and Maryam Saberi-Karimian and Mohammad Hashemi and Doust, {Fatemeh N.S.} and Mohsen Nematy and Bahre, {Ensieh A.} and Aghaei-Bakhtiari, {Seyed H.} and Hamideh Ghazizadeh and Hamideh Safarian-Bana and Niloofar Shabani and Habibollah Esmaily and Ferns, {Gordon A.} and Alireza Pasdar and Majid Ghayour-Mobarhan",

note = "Funding Information: We would like to thank Mashhad University of Medical Sciences Research Council for their financial supports. ",

year = "2023",

month = jul,

doi = "10.1002/mgg3.2173",

language = "English",

volume = "11",

journal = "Molecular Genetics and Genomic Medicine",

issn = "2324-9269",

publisher = "John Wiley & Sons Inc.",

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TY - JOUR

T1 - Association between the rs2241883 polymorphism of the fatty acid-binding protein-1 (FABP1) gene and obesity in a population of MASHAD study cohort

AU - Valizadeh, Mohsen

AU - Aghasizadeh, Malihe

AU - Shaghi, Fatemeh

AU - Moradi, Ali

AU - Afshari, Haleh S.T.

AU - Zare-Feyzabadi, Reza

AU - Saberi-Karimian, Maryam

AU - Hashemi, Mohammad

AU - Doust, Fatemeh N.S.

AU - Nematy, Mohsen

AU - Bahre, Ensieh A.

AU - Aghaei-Bakhtiari, Seyed H.

AU - Ghazizadeh, Hamideh

AU - Safarian-Bana, Hamideh

AU - Shabani, Niloofar

AU - Esmaily, Habibollah

AU - Ferns, Gordon A.

AU - Pasdar, Alireza

AU - Ghayour-Mobarhan, Majid

N1 - Funding Information: We would like to thank Mashhad University of Medical Sciences Research Council for their financial supports.

PY - 2023/7

Y1 - 2023/7

N2 - BACKGROUND AND AIMS: The fatty acid-binding proteins (FABPs) gene polymorphisms are related to several metabolic properties. We investigated the association of SNPs rs2241883 of FABP 1 gene with obesity to evaluate the role of FABP1 gene in the pathogenesis of obesity in the population of MASHAD study cohort.METHODS: In this cross-sectional study, 2731 individuals (1883 Obese and 848 nonobese) aged 35 to 65 years old, were enrolled from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study cohort. DNA Quantitation was determined using the NanoDrop®-1000 instrument (NanoDrop-Technologies). The rs2241883 polymorphisms were genotyped by double ARMs PCR (double amplification refractory mutation system) reactions. Data analysis was carried out using SPSS 22 and a p < 0.05 was set for statistical significance.RESULTS: The results showed that after adjusting for confounding factors, subjects having the CC genotype for rs2241883 polymorphism were at a higher risk of BMI ≥ 30 mg/kg 2 with OR of 1.79 (CI = 1.05-3.07; p = 0.03) and 1.76 (CI = 1.04-2.99; p = 0.04) comparing with reference group using codominant and dominant models, respectively. CONCLUSION: The results showed that CC genotype for rs2241883 polymorphism is related to an increased risk of the obesity in dominant and codominant models in a population of MASHAD study cohort.

AB - BACKGROUND AND AIMS: The fatty acid-binding proteins (FABPs) gene polymorphisms are related to several metabolic properties. We investigated the association of SNPs rs2241883 of FABP 1 gene with obesity to evaluate the role of FABP1 gene in the pathogenesis of obesity in the population of MASHAD study cohort.METHODS: In this cross-sectional study, 2731 individuals (1883 Obese and 848 nonobese) aged 35 to 65 years old, were enrolled from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study cohort. DNA Quantitation was determined using the NanoDrop®-1000 instrument (NanoDrop-Technologies). The rs2241883 polymorphisms were genotyped by double ARMs PCR (double amplification refractory mutation system) reactions. Data analysis was carried out using SPSS 22 and a p < 0.05 was set for statistical significance.RESULTS: The results showed that after adjusting for confounding factors, subjects having the CC genotype for rs2241883 polymorphism were at a higher risk of BMI ≥ 30 mg/kg 2 with OR of 1.79 (CI = 1.05-3.07; p = 0.03) and 1.76 (CI = 1.04-2.99; p = 0.04) comparing with reference group using codominant and dominant models, respectively. CONCLUSION: The results showed that CC genotype for rs2241883 polymorphism is related to an increased risk of the obesity in dominant and codominant models in a population of MASHAD study cohort.

KW - ARMs PCR

KW - atherosclerosis

KW - FABPs

KW - genotype

KW - metabolic syndrome

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U2 - 10.1002/mgg3.2173

DO - 10.1002/mgg3.2173

M3 - Article

C2 - 37026586

AN - SCOPUS:85151949345

SN - 2324-9269

VL - 11

JO - Molecular Genetics and Genomic Medicine

JF - Molecular Genetics and Genomic Medicine

IS - 7

M1 - e2173

ER -

Association between the rs2241883 polymorphism of the fatty acid-binding protein-1 (FABP1) gene and obesity in a population of MASHAD study cohort

Abstract

Bibliographical note

Data Availability Statement

Keywords

UN SDGs

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