Association of macro-and micro-nutrients dietary intakes with rs2241883 genetic variants of FABP 1 gene in MASHAD study population

Mohsen Valizadeh, Maliheh Aghasizadeh, Maryam Saberi-Karimian, Mina Safari, Mohadese Rohban, Hamideh Safarian Bana, Reza Zare-Feyzabadi, Haleh Sadat Tavakkol Afshari, Ali Moradi, Najmeh Ahangari, Mohammad Hashemi, Mohsen Nematy, Ensieh Akbarpour Bahre, Seyed Hamid Aghaei-Bakhtiari, Hamideh Ghazizadeh, Habibollah Esmaily, Gordon A. Ferns, Alireza Pasdar* (Corresponding Author), Majid Ghayour-Mobarhan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Introduction: There is a relationship between macro-nutrient-intakes and the genes implicated in lipid metabolism. In this study, we assessed the association between macro-and micro-nutrients dietary intakes with rs2241883 genetic variants of the FABP1 gene. Methods: For this cross-sectional study 2737 subjects (including 2203 subjects with dyslipidemia and 534 healthy volunteers) were enrolled as part of the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study cohort. Dyslipidemia was defined based on the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). A NanoDrop®-1000 instrument was used to do the quantitation of DNA. The rs2241883 polymorphisms were genotyped using double ARMs PCR reactions. Genotyping reagents were obtained from Applied Biosystems. Dietary intake was evaluated using a food frequency questionnaire (FFQ) and validated by 2 consecutive 24-h food recalls. Results: The results showed no significant association between subjects with and without dyslipidemia (P > 0.05), except for the zinc to copper ratio, the value for which was higher in the subjects with dyslipidemia (4.78 (1.62)) when compared to subjects without dyslipidemia (4.68 (1.82)) (p = 0.05). Using different genetic models we found that zinc and copper were significantly different in the additive (p = 0.01) and dominant (p = 0.01) genetic models. Although, this association was no longer significant after adjusting for confounding factors. Conclusions: There were no associations between macro-and micro-nutrient dietary intakes with rs2241883 genetic variants after adjusting for confounding factors in the MASHAD study population.

Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournalClinical nutrition ESPEN
Publication statusPublished - 2 Sept 2021

Bibliographical note

Funding Information:
This research was supported by Mashhad University of Medical Sciences . The authors would like to thank all volunteers participated in this research.


  • Dyslipidemia
  • Fatty acid-binding proteins
  • Polymorphism
  • rs2241883


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