TY - JOUR
T1 - Association of the dysbindin gene with bipolar affective disorder
AU - Breen, Gerome
AU - Prata, Diana
AU - Osborne, Sarah
AU - Munro, Janet
AU - Sinclair, Maggie
AU - Li, Tao
AU - Staddon, Susan
AU - Dempster, David
AU - Sainz, Ricardo
AU - Arroyo, Barbara
AU - Kerwin, Robert W.
AU - St. Clair, David
AU - Collier, David
PY - 2006/9
Y1 - 2006/9
N2 - Objective: In the study of bipolar affective disorder and schizophrenia, there is some evidence suggesting a phenotypic and genetic overlap between the two disorders. A possible link between bipolar affective disorder and schizophrenia remains arguable, however. The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and tested this hypothesis using a case-control design study. Method: Participants included 213 patients with bipolar I disorder and 197 comparison subjects. In each subject, 10 polymorphisms in the dysbindin gene were genotyped and assessed. Results: Two polymorphisms showed individual genotypic association with bipolar I disorder. Multiple marker haplotypes were more strongly associated, with the rarer of the two common haplotypes being overrepresented in the patients with bipolar affective disorder. A similar finding was reported in patients with schizophrenia in a previous study. Conclusions: Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia. The existence of shared genetic risk factors will, in time, lead to changes in the current nosology of major psychoses.
AB - Objective: In the study of bipolar affective disorder and schizophrenia, there is some evidence suggesting a phenotypic and genetic overlap between the two disorders. A possible link between bipolar affective disorder and schizophrenia remains arguable, however. The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and tested this hypothesis using a case-control design study. Method: Participants included 213 patients with bipolar I disorder and 197 comparison subjects. In each subject, 10 polymorphisms in the dysbindin gene were genotyped and assessed. Results: Two polymorphisms showed individual genotypic association with bipolar I disorder. Multiple marker haplotypes were more strongly associated, with the rarer of the two common haplotypes being overrepresented in the patients with bipolar affective disorder. A similar finding was reported in patients with schizophrenia in a previous study. Conclusions: Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia. The existence of shared genetic risk factors will, in time, lead to changes in the current nosology of major psychoses.
UR - http://www.scopus.com/inward/record.url?scp=33749076012&partnerID=8YFLogxK
U2 - 10.1176/appi.ajp.163.9.1636
DO - 10.1176/appi.ajp.163.9.1636
M3 - Article
C2 - 16946192
AN - SCOPUS:33749076012
SN - 0002-953X
VL - 163
SP - 1636
EP - 1638
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 9
ER -