Associations between life course longitudinal growth and hip shapes at ages 60 to 64 years: evidence from the MRC National Survey of Health and Development

Katherine Staines; Fiona Saunders; Alex Ireland; Richard Malcolm Aspden; Jenny Gregory; Rebecca Hardy; Rachel  Cooper

doi:10.1136/rmdopen-2023-003816

Associations between life course longitudinal growth and hip shapes at ages 60 to 64 years: evidence from the MRC National Survey of Health and Development

Katherine Staines^* (Corresponding Author), Fiona Saunders, Alex Ireland, Richard Malcolm Aspden, Jenny Gregory, Rebecca Hardy, Rachel Cooper

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: We sought to examine associations between height gain across childhood and adolescence with hip shape in individuals aged 60 - 64 years from the MRC National Survey of Health and Development, a nationally representative British birth cohort.
Methods: Height was measured at ages 2, 4, 6, 7, 11 and 15 years, and self-reported at age 20 years. Ten modes of variation in hip shape (HM1-10), described by statistical shape models, were previously ascertained from DXA images taken at ages 60 - 64 years. Associations between (1) height at each age (2) Super-Imposition by Translation And Rotation (SITAR) growth curve variables of height size, tempo and velocity, and (3) height gain during specific periods of childhood and adolescence, and HM1-10 were tested.
Results: Faster growth velocity was associated with a wider, flatter femoral head and neck, as described by positive scores for HM6 (regression coefficient 0.014; 95%CI, 0.08–0.019; P<0.001) and HM7 (regression coefficient 0.07; 95%CI, 0.002-0.013; P=0.009), and negative scores for HM10 (regression coefficient -0.006; 95%CI, -0.011-0.00, P=0.04) and HM2 (males only, regression coefficient -0.017; 95%CI, -0.026 - -0.09; P<0.001). Similar associations were
observed with greater height size and later height tempo. Examination of height gains during specific periods of childhood and adolescence identified those during the adolescence period as being most consistently associated.
Conclusion: Our analyses suggest that individual growth patterns, particularly in the adolescent period, are associated with modest variations in hip shape at 60 - 64 years, which are consistent with features seen in osteoarthritis.

Original language	English
Number of pages	9
Journal	RMD Open
Volume	10
Issue number	2
Early online date	10 Apr 2024
DOIs	https://doi.org/10.1136/rmdopen-2023-003816
Publication status	Published - 10 Apr 2024

Bibliographical note

Acknowledgements
The authors thank all the participants of the MRC National Survey of Health and Development and all staff involved in data collection and data entry, as well as Prof. Tim Cole (SITAR growth curve analysis).
Funding
The authors would like to acknowledge the UK Medical Research Council for funding to KAS (MR/V033506/1 & MR/R022240/2). This project was further funded by the UK Medical Research Council (MR/L010399/1), which supported FRS. The NSHD is funded by the UK Medical Research Council. RC acknowledges support from the National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust, Cumbria, Northumberland, Tyne and Wear NHS
Foundation Trust and Newcastle University. RC also receives support as part of a generous donation made by the McArdle family to Newcastle University for research that will benefit the lives of older people in the UK. The funders were not involved in the study design, collection, analysis and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. The views expressed in this publication are those of the authors and not necessarily those of UK Research and Innovation, the National Institute for Health and Care Research, the Department of Health and Social Care, the National Health Service or the McArdle family.

Data Availability Statement

Data used in this publication are available to bona fide researchers upon request to the NSHD 370 Data Sharing Committee via a standard application procedure. Further details can be found at 371 http://www.nshd.mrc.ac.uk/data. doi: 10.5522/NSHD/Q101 and 10.5522/NSHD/S102A

Keywords

Birth cohort
growth
life course
hip shape
osteoarthritis
SITAR

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Cite this

@article{9e0a424ebf334e359432b126f7f5d5cc,

title = "Associations between life course longitudinal growth and hip shapes at ages 60 to 64 years: evidence from the MRC National Survey of Health and Development",

abstract = "Objective: We sought to examine associations between height gain across childhood and adolescence with hip shape in individuals aged 60 - 64 years from the MRC National Survey of Health and Development, a nationally representative British birth cohort.Methods: Height was measured at ages 2, 4, 6, 7, 11 and 15 years, and self-reported at age 20 years. Ten modes of variation in hip shape (HM1-10), described by statistical shape models, were previously ascertained from DXA images taken at ages 60 - 64 years. Associations between (1) height at each age (2) Super-Imposition by Translation And Rotation (SITAR) growth curve variables of height size, tempo and velocity, and (3) height gain during specific periods of childhood and adolescence, and HM1-10 were tested.Results: Faster growth velocity was associated with a wider, flatter femoral head and neck, as described by positive scores for HM6 (regression coefficient 0.014; 95%CI, 0.08–0.019; P<0.001) and HM7 (regression coefficient 0.07; 95%CI, 0.002-0.013; P=0.009), and negative scores for HM10 (regression coefficient -0.006; 95%CI, -0.011-0.00, P=0.04) and HM2 (males only, regression coefficient -0.017; 95%CI, -0.026 - -0.09; P<0.001). Similar associations wereobserved with greater height size and later height tempo. Examination of height gains during specific periods of childhood and adolescence identified those during the adolescence period as being most consistently associated.Conclusion: Our analyses suggest that individual growth patterns, particularly in the adolescent period, are associated with modest variations in hip shape at 60 - 64 years, which are consistent with features seen in osteoarthritis. ",

keywords = "Birth cohort, growth, life course, hip shape, osteoarthritis, SITAR",

author = "Katherine Staines and Fiona Saunders and Alex Ireland and Aspden, {Richard Malcolm} and Jenny Gregory and Rebecca Hardy and Rachel Cooper",

note = "Acknowledgements The authors thank all the participants of the MRC National Survey of Health and Development and all staff involved in data collection and data entry, as well as Prof. Tim Cole (SITAR growth curve analysis). Funding The authors would like to acknowledge the UK Medical Research Council for funding to KAS (MR/V033506/1 & MR/R022240/2). This project was further funded by the UK Medical Research Council (MR/L010399/1), which supported FRS. The NSHD is funded by the UK Medical Research Council. RC acknowledges support from the National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust, Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust and Newcastle University. RC also receives support as part of a generous donation made by the McArdle family to Newcastle University for research that will benefit the lives of older people in the UK. The funders were not involved in the study design, collection, analysis and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. The views expressed in this publication are those of the authors and not necessarily those of UK Research and Innovation, the National Institute for Health and Care Research, the Department of Health and Social Care, the National Health Service or the McArdle family. ",

year = "2024",

month = apr,

day = "10",

doi = "10.1136/rmdopen-2023-003816",

language = "English",

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journal = "RMD Open",

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publisher = "BMJ Publishing Group",

number = "2",

}

TY - JOUR

T1 - Associations between life course longitudinal growth and hip shapes at ages 60 to 64 years

T2 - evidence from the MRC National Survey of Health and Development

AU - Staines, Katherine

AU - Saunders, Fiona

AU - Ireland, Alex

AU - Aspden, Richard Malcolm

AU - Gregory, Jenny

AU - Hardy, Rebecca

AU - Cooper, Rachel

N1 - Acknowledgements The authors thank all the participants of the MRC National Survey of Health and Development and all staff involved in data collection and data entry, as well as Prof. Tim Cole (SITAR growth curve analysis). Funding The authors would like to acknowledge the UK Medical Research Council for funding to KAS (MR/V033506/1 & MR/R022240/2). This project was further funded by the UK Medical Research Council (MR/L010399/1), which supported FRS. The NSHD is funded by the UK Medical Research Council. RC acknowledges support from the National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust, Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust and Newcastle University. RC also receives support as part of a generous donation made by the McArdle family to Newcastle University for research that will benefit the lives of older people in the UK. The funders were not involved in the study design, collection, analysis and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. The views expressed in this publication are those of the authors and not necessarily those of UK Research and Innovation, the National Institute for Health and Care Research, the Department of Health and Social Care, the National Health Service or the McArdle family.

PY - 2024/4/10

Y1 - 2024/4/10

N2 - Objective: We sought to examine associations between height gain across childhood and adolescence with hip shape in individuals aged 60 - 64 years from the MRC National Survey of Health and Development, a nationally representative British birth cohort.Methods: Height was measured at ages 2, 4, 6, 7, 11 and 15 years, and self-reported at age 20 years. Ten modes of variation in hip shape (HM1-10), described by statistical shape models, were previously ascertained from DXA images taken at ages 60 - 64 years. Associations between (1) height at each age (2) Super-Imposition by Translation And Rotation (SITAR) growth curve variables of height size, tempo and velocity, and (3) height gain during specific periods of childhood and adolescence, and HM1-10 were tested.Results: Faster growth velocity was associated with a wider, flatter femoral head and neck, as described by positive scores for HM6 (regression coefficient 0.014; 95%CI, 0.08–0.019; P<0.001) and HM7 (regression coefficient 0.07; 95%CI, 0.002-0.013; P=0.009), and negative scores for HM10 (regression coefficient -0.006; 95%CI, -0.011-0.00, P=0.04) and HM2 (males only, regression coefficient -0.017; 95%CI, -0.026 - -0.09; P<0.001). Similar associations wereobserved with greater height size and later height tempo. Examination of height gains during specific periods of childhood and adolescence identified those during the adolescence period as being most consistently associated.Conclusion: Our analyses suggest that individual growth patterns, particularly in the adolescent period, are associated with modest variations in hip shape at 60 - 64 years, which are consistent with features seen in osteoarthritis.

AB - Objective: We sought to examine associations between height gain across childhood and adolescence with hip shape in individuals aged 60 - 64 years from the MRC National Survey of Health and Development, a nationally representative British birth cohort.Methods: Height was measured at ages 2, 4, 6, 7, 11 and 15 years, and self-reported at age 20 years. Ten modes of variation in hip shape (HM1-10), described by statistical shape models, were previously ascertained from DXA images taken at ages 60 - 64 years. Associations between (1) height at each age (2) Super-Imposition by Translation And Rotation (SITAR) growth curve variables of height size, tempo and velocity, and (3) height gain during specific periods of childhood and adolescence, and HM1-10 were tested.Results: Faster growth velocity was associated with a wider, flatter femoral head and neck, as described by positive scores for HM6 (regression coefficient 0.014; 95%CI, 0.08–0.019; P<0.001) and HM7 (regression coefficient 0.07; 95%CI, 0.002-0.013; P=0.009), and negative scores for HM10 (regression coefficient -0.006; 95%CI, -0.011-0.00, P=0.04) and HM2 (males only, regression coefficient -0.017; 95%CI, -0.026 - -0.09; P<0.001). Similar associations wereobserved with greater height size and later height tempo. Examination of height gains during specific periods of childhood and adolescence identified those during the adolescence period as being most consistently associated.Conclusion: Our analyses suggest that individual growth patterns, particularly in the adolescent period, are associated with modest variations in hip shape at 60 - 64 years, which are consistent with features seen in osteoarthritis.

KW - Birth cohort

KW - growth

KW - life course

KW - hip shape

KW - osteoarthritis

KW - SITAR

U2 - 10.1136/rmdopen-2023-003816

DO - 10.1136/rmdopen-2023-003816

M3 - Article

C2 - 38599656

SN - 2056-5933

VL - 10

JO - RMD Open

JF - RMD Open

IS - 2

ER -

Associations between life course longitudinal growth and hip shapes at ages 60 to 64 years: evidence from the MRC National Survey of Health and Development

Abstract

Bibliographical note

Data Availability Statement

Keywords

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