Abstract
Aim
To establish patient factors associated with a successful colon capsule endoscopy (CCE) test.
Methods
This prospective cohort study used data collected from patients who underwent CCE as part of the ScotCap evaluation prior to April 2020. A CCE was defined as successful if the capsule visualised the whole colon and rectum (complete test) with sufficient bowel cleansing to assess the colonic mucosa (adequate bowel preparation). Symptomatic and surveillance patient factors were analysed for
associations with a successful test, complete test, adequate bowel preparation and requirement for further procedure using univariate, multivariate logistic, and least absolute shrinkage and selection operator regression.
Results
Data from 263 symptomatic and 137 surveillance patients were analysed. There was an association between symptomatic patient’s age and successful test (Odds ratio [OR] 0.97, 95% confidence interval [CI] 0.95-0.99), adequate bowel preparation (OR 0.97, 95% CI 0.94 – 1.00) and further procedure requirement (OR 1.04, 95% CI 1.02-1.06). Symptomatic patients with a faecal
immunochemical test result between 10-399 µg/g were associated with a further procedure (OR 2.32, 95% CI 1.23 to 4.48). Patients undergoing surveillance for previous colorectal cancer (OR 0.42, 95% CI 0.18-0.97), who had previous bowel resection surgery (OR 0.43, 95% CI 0.19-0.98) or were on
beta blocker medication (OR 0.32, 95% CI 0.11-0.88) were associated with further procedure requirement.
Conclusions
Younger age was associated among symptomatic patients with obtaining a successful test. Clinicians could consider patient selection based on these results to improve the rate of successful testing in clinical practice.
To establish patient factors associated with a successful colon capsule endoscopy (CCE) test.
Methods
This prospective cohort study used data collected from patients who underwent CCE as part of the ScotCap evaluation prior to April 2020. A CCE was defined as successful if the capsule visualised the whole colon and rectum (complete test) with sufficient bowel cleansing to assess the colonic mucosa (adequate bowel preparation). Symptomatic and surveillance patient factors were analysed for
associations with a successful test, complete test, adequate bowel preparation and requirement for further procedure using univariate, multivariate logistic, and least absolute shrinkage and selection operator regression.
Results
Data from 263 symptomatic and 137 surveillance patients were analysed. There was an association between symptomatic patient’s age and successful test (Odds ratio [OR] 0.97, 95% confidence interval [CI] 0.95-0.99), adequate bowel preparation (OR 0.97, 95% CI 0.94 – 1.00) and further procedure requirement (OR 1.04, 95% CI 1.02-1.06). Symptomatic patients with a faecal
immunochemical test result between 10-399 µg/g were associated with a further procedure (OR 2.32, 95% CI 1.23 to 4.48). Patients undergoing surveillance for previous colorectal cancer (OR 0.42, 95% CI 0.18-0.97), who had previous bowel resection surgery (OR 0.43, 95% CI 0.19-0.98) or were on
beta blocker medication (OR 0.32, 95% CI 0.11-0.88) were associated with further procedure requirement.
Conclusions
Younger age was associated among symptomatic patients with obtaining a successful test. Clinicians could consider patient selection based on these results to improve the rate of successful testing in clinical practice.
| Original language | English |
|---|---|
| Pages (from-to) | 2383-2391 |
| Number of pages | 8 |
| Journal | Colorectal Disease |
| Volume | 25 |
| Issue number | 12 |
| Early online date | 25 Oct 2023 |
| DOIs | |
| Publication status | Published - Dec 2023 |
Bibliographical note
Funding statementThis study was funded by an NHS Highland Research Development and Innovation grant.
Acknowledgements
We would like to thank all patients and staff involved in the ScotCap evaluation. We would also like to thank The Data Lab for their contribution to the project.
Data Availability Statement
The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Access to Document
- MacLeod_etal_CD_Association_Between_Patient_AAM
This accepted author manuscript has been made open access under the University of Aberdeen Rights Retention Policy. It is available under a Creative Commons Attribution license https://creativecommons.org/licenses/by/4.0/ Final published version available at https://doi.org/10.1111/codi.16771