Asymptomatic bacteriuria and urinary tract infection in pregnant women with and without diabetes: Cohort study

Caroline Schneeberger*, Jan Jaap H.M. Erwich, Edwin R. van den Heuvel, Ben W.J. Mol, Alewijn Ott, Suzanne E. Geerlings

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Objective: To compare the prevalence of asymptomatic bacteriuria (ASB) and the incidence of urinary tract infection (UTI) in pregnant women with and without diabetes mellitus (DM) or gestational DM (GDM). Study design: We performed a cohort study in five hospitals and two midwifery clinics in the Netherlands. Pregnant women with and without DM or GDM were screened for the presence of ASB around 12 and 32 weeks’ gestation. Characteristics of participants as well as outcome data were collected from questionnaires and medical records. ASB was defined as the growth of at least 10e5 cfu/ml isolated from the urine of a woman without UTI complaints. UTI was considered to be present when a treating physician had diagnosed UTI and prescribed antibiotics. Results: We studied 202 women with and 272 women without DM or GDM. Of all women 31.7% with and 94.9% without DM or GDM provided a week 12 sample. The prevalence of ASB was comparable in women with and without DM or GDM (12 weeks’ n = 322; 4.7% and 2.3%; relative risk (RR) 2.02; 95% confidence interval (CI) 0.52–7.84; 32 weeks’ n = 422; 3.2% and 3.0%; RR 1.06; 95% CI 0.36–3.09), as was the incidence of UTI (16.8% and 12.9%; RR 1.31; 95% CI 0.85–2.02). Neither ASB nor UTI were associated with preterm birth or babies being small for gestational age. Conclusion: In pregnant women with and women without DM or GDM, the overall prevalence of ASB was low. Neither ASB nor UTI did differ significantly between the groups. Our data discourage a routine ASB screen and treat policy in pregnant women with DM or GDM.

Original languageEnglish
Pages (from-to)176-181
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Early online date7 Dec 2017
Publication statusPublished - Mar 2018

Bibliographical note

UMCG, Groningen, the Netherlands.

We would like to thank all participating laboratories (department of Medical Microbiology of Certe in Groningen, Academic Medical Center (AMC) in Amsterdam and Jeroen Bosch hospital (JBZ) in Den Bosch), hospitals (department of Obstetrics and Gynaecology of the university medical Centre of Groningen (UMCG) in Groningen, Martini Hospital (MZH) in Groningen, Onze Lieve Vrouwen Gasthuis (OLVG) in Amsterdam, AMC in Amsterdam and JBZ in Den Bosch) and midwifery clinics (‘Verloskundige Stadsprakijk’ (VSP) in Groningen and ‘VIDA’ in Amsterdam) for their contributions to this study, particularly the midwifes, gynaecologists, laboratory analysts, administrative office and all women who participated in this trial. Furthermore we thank the UMCG in Groningen, the Netherlands for their financial support.


  • Asymptomatic bacteriuria
  • Diabetes mellitus
  • Pregnancy
  • Urinary tract infection


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