Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts

Lucy Thompson; Christopher Gillberg; Sara Landberg; Anne-Katrin Kantzer; Carmela Miniscalco; Martina Barnevik Olsson; Mats A Eriksson; Elisabeth Fernell

doi:10.1007/s10803-018-03871-4

Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts

Lucy Thompson^* (Corresponding Author), Christopher Gillberg, Sara Landberg, Anne-Katrin Kantzer, Carmela Miniscalco, Martina Barnevik Olsson, Mats A Eriksson, Elisabeth Fernell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n=301) and subdivided according to history of regression. Those with regression (n=62), 20.5% of the combined cohort, were contrasted with those without regression (n=241) at first assessment (age range 19–60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p<.001), language development (p<.001), and to severity of autism (p<.01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed ‘from normal’ and those who had regressed ‘from low’ functioning.

Original language	English
Pages (from-to)	2281-2290
Number of pages	10
Journal	Journal of Autism and Developmental Disorders
Volume	49
Early online date	4 Feb 2019
DOIs	https://doi.org/10.1007/s10803-018-03871-4
Publication status	Published - 15 Jun 2019

Keywords

Autism
ASD
Regressive autism
Non-regressive autism
Intellectual developmental disorder
Developmental language disorder

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Thompson_et_al_JADD_AutismWithAnd_VoR
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Final published version, 612 KBLicence: CC BY

Cite this

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title = "Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts",

abstract = "Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n=301) and subdivided according to history of regression. Those with regression (n=62), 20.5% of the combined cohort, were contrasted with those without regression (n=241) at first assessment (age range 19–60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p<.001), language development (p<.001), and to severity of autism (p<.01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed {\textquoteleft}from normal{\textquoteright} and those who had regressed {\textquoteleft}from low{\textquoteright} functioning.",

keywords = "Autism, ASD, Regressive autism, Non-regressive autism, Intellectual developmental disorder, Developmental language disorder",

author = "Lucy Thompson and Christopher Gillberg and Sara Landberg and Anne-Katrin Kantzer and Carmela Miniscalco and {Barnevik Olsson}, Martina and Eriksson, {Mats A} and Elisabeth Fernell",

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month = jun,

day = "15",

doi = "10.1007/s10803-018-03871-4",

language = "English",

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T2 - A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts

AU - Thompson, Lucy

AU - Gillberg, Christopher

AU - Landberg, Sara

AU - Kantzer, Anne-Katrin

AU - Miniscalco, Carmela

AU - Barnevik Olsson, Martina

AU - Eriksson, Mats A

AU - Fernell, Elisabeth

PY - 2019/6/15

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AB - Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n=301) and subdivided according to history of regression. Those with regression (n=62), 20.5% of the combined cohort, were contrasted with those without regression (n=241) at first assessment (age range 19–60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p<.001), language development (p<.001), and to severity of autism (p<.01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed ‘from normal’ and those who had regressed ‘from low’ functioning.

KW - Autism

KW - ASD

KW - Regressive autism

KW - Non-regressive autism

KW - Intellectual developmental disorder

KW - Developmental language disorder

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JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

ER -

Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts

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Keywords

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