Bayesian clinical trial designs: Another option for trauma trials?

Jan O. Jansen; Philip Pallmann; Graeme MacLennan; Marion K. Campbell; UK-REBOA Trial Investigators

doi:10.1097/TA.0000000000001638

Bayesian clinical trial designs: Another option for trauma trials?

Jan O. Jansen, Philip Pallmann, Graeme MacLennan, Marion K. Campbell, UK-REBOA Trial Investigators

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Abstract

Conducting clinical trials in trauma care is challenging. As new treatments become available, we are faced with the dilemma of how to confirm their effectiveness, and strengthen the evidence base. Randomized controlled trials are the gold standard, but target groups in trauma care are often small and specialized, making the classical approach to trial design difficult. Bayesian designs represent an innovative means of increasing trial efficiency, and conducting trials with more realistic sample sizes. This article examines the design of such trials, using the UK-REBOA Trial as an example.

Original language	English
Pages (from-to)	736-741
Number of pages	6
Journal	The journal of trauma and acute care surgery
Volume	83
Issue number	4
Early online date	8 Jul 2017
DOIs	https://doi.org/10.1097/TA.0000000000001638
Publication status	Published - Oct 2017

Bibliographical note

The UK-REBOA Trial is funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme (project number 14/199/09).
PP was supported by the MRC Network of Hubs for Trials Methodology Research
(MR/L004933/1-R/N/P/B1).

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10.1097/TA.0000000000001638Licence: CC BY

Bayesian clinical trial designs: Another option for trauma trials?
This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
Final published version, 392 KBLicence: CC BY

Cite this

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title = "Bayesian clinical trial designs: Another option for trauma trials?",

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Bayesian clinical trial designs: Another option for trauma trials?

Abstract

Bibliographical note

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