Beneficial effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of C-reactive protein among postmenopausal women: An updated systematic review and meta-analysis of randomized controlled trials

Mitra Hariri; Ahmad Ghasemi; Hamid Reza Baradaran; Ensieyh Mollanoroozy; Ali Gholami

doi:10.1016/j.ctim.2021.102715

Beneficial effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of C-reactive protein among postmenopausal women: An updated systematic review and meta-analysis of randomized controlled trials

Mitra Hariri, Ahmad Ghasemi, Hamid Reza Baradaran, Ensieyh Mollanoroozy, Ali Gholami^* (Corresponding Author)

^*Corresponding author for this work

Applied Health Sciences

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

5 Downloads (Pure)

Abstract

BACKGROUND: Scientists suggest that soy isoflavones or the combination of soy isoflavones and soy protein may have beneficial effects on inflammation. Thus, the present study aims at conducting a systematic review and meta-analysis on randomized controlled trials (RCTs) in which the effect of soy isoflavones and the combination of soy isoflavones and soy protein on serum concentration of C-reactive protein (CRP) among postmenopausal women is assessed.

METHODS AND MATERIALS: A literature searching was done to identify a breadth of related references in PubMed, Scopus, ISI Web of Science, Cochrane Library, and Clinicaltrials.gov up to December 2020. The mean change from baseline in the CRP concentrations and its standard deviation (SD) for both intervention and comparison groups were used to calculate the effect size. The summary of the overall effects and heterogeneity was estimated by using the DerSimonian and Laird random effects model. The protocol was registered with PROSPERO (No. CRD42020166053).

RESULTS: This study considered 23 articles for systematic review and 19 articles for meta-analysis. The overall effect presented a non-significant effect of soy isoflavones on serum CRP concentrations (WMD = 0.08 mg/L, 95% CI: -0.08, 0.24; p = 0.302) and the overall effect of the combination of soy isoflavones and soy protein indicated non-significant effect in serum levels of CRP (WMD= -0.02 mg/L 95% CI: -0.12, 0.08; p = 0.715).

CONCLUSION: Published RCTs did not provide strong evidence regarding beneficial effect of soy isoflavones or the combination of soy isoflavones and soy protein on serum CRP concentration among postmenopausal women.

Original language	English
Article number	102715
Number of pages	12
Journal	Complementary Therapies in Medicine
Volume	59
Early online date	27 Mar 2021
DOIs	https://doi.org/10.1016/j.ctim.2021.102715
Publication status	Published - 1 Jun 2021

Bibliographical note

Financial support: This systematic review and meta-analysis was financially supported by Neyshabur University of Medical Sciences (Grant number: 98-01-149. Ethical code: IR.NUMS.REC.1399.006).

We are extremely grateful to the data collection team at the Neyshabur University of Medical Sciences.

Keywords

Soy isoflavones
Soy protein
Postmenopausal women
C-reactive protein

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Hariri, M., Ghasemi, A., Baradaran, H. R., Mollanoroozy, E., & Gholami, A. (2021). Beneficial effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of C-reactive protein among postmenopausal women: An updated systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine, 59, Article 102715. https://doi.org/10.1016/j.ctim.2021.102715

Beneficial effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of C-reactive protein among postmenopausal women: An updated systematic review and meta-analysis of randomized controlled trials. / Hariri, Mitra; Ghasemi, Ahmad; Baradaran, Hamid Reza et al.
In: Complementary Therapies in Medicine, Vol. 59, 102715, 01.06.2021.

Research output: Contribution to journal › Review article › peer-review

Hariri, M, Ghasemi, A, Baradaran, HR, Mollanoroozy, E & Gholami, A 2021, 'Beneficial effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of C-reactive protein among postmenopausal women: An updated systematic review and meta-analysis of randomized controlled trials', Complementary Therapies in Medicine, vol. 59, 102715. https://doi.org/10.1016/j.ctim.2021.102715

Hariri M, Ghasemi A, Baradaran HR, Mollanoroozy E, Gholami A. Beneficial effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of C-reactive protein among postmenopausal women: An updated systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine. 2021 Jun 1;59:102715. Epub 2021 Mar 27. doi: 10.1016/j.ctim.2021.102715

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abstract = "BACKGROUND: Scientists suggest that soy isoflavones or the combination of soy isoflavones and soy protein may have beneficial effects on inflammation. Thus, the present study aims at conducting a systematic review and meta-analysis on randomized controlled trials (RCTs) in which the effect of soy isoflavones and the combination of soy isoflavones and soy protein on serum concentration of C-reactive protein (CRP) among postmenopausal women is assessed.METHODS AND MATERIALS: A literature searching was done to identify a breadth of related references in PubMed, Scopus, ISI Web of Science, Cochrane Library, and Clinicaltrials.gov up to December 2020. The mean change from baseline in the CRP concentrations and its standard deviation (SD) for both intervention and comparison groups were used to calculate the effect size. The summary of the overall effects and heterogeneity was estimated by using the DerSimonian and Laird random effects model. The protocol was registered with PROSPERO (No. CRD42020166053).RESULTS: This study considered 23 articles for systematic review and 19 articles for meta-analysis. The overall effect presented a non-significant effect of soy isoflavones on serum CRP concentrations (WMD = 0.08 mg/L, 95% CI: -0.08, 0.24; p = 0.302) and the overall effect of the combination of soy isoflavones and soy protein indicated non-significant effect in serum levels of CRP (WMD= -0.02 mg/L 95% CI: -0.12, 0.08; p = 0.715).CONCLUSION: Published RCTs did not provide strong evidence regarding beneficial effect of soy isoflavones or the combination of soy isoflavones and soy protein on serum CRP concentration among postmenopausal women.",

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author = "Mitra Hariri and Ahmad Ghasemi and Baradaran, {Hamid Reza} and Ensieyh Mollanoroozy and Ali Gholami",

note = "Financial support: This systematic review and meta-analysis was financially supported by Neyshabur University of Medical Sciences (Grant number: 98-01-149. Ethical code: IR.NUMS.REC.1399.006). We are extremely grateful to the data collection team at the Neyshabur University of Medical Sciences.",

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AU - Ghasemi, Ahmad

AU - Baradaran, Hamid Reza

AU - Mollanoroozy, Ensieyh

AU - Gholami, Ali

N1 - Financial support: This systematic review and meta-analysis was financially supported by Neyshabur University of Medical Sciences (Grant number: 98-01-149. Ethical code: IR.NUMS.REC.1399.006). We are extremely grateful to the data collection team at the Neyshabur University of Medical Sciences.

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N2 - BACKGROUND: Scientists suggest that soy isoflavones or the combination of soy isoflavones and soy protein may have beneficial effects on inflammation. Thus, the present study aims at conducting a systematic review and meta-analysis on randomized controlled trials (RCTs) in which the effect of soy isoflavones and the combination of soy isoflavones and soy protein on serum concentration of C-reactive protein (CRP) among postmenopausal women is assessed.METHODS AND MATERIALS: A literature searching was done to identify a breadth of related references in PubMed, Scopus, ISI Web of Science, Cochrane Library, and Clinicaltrials.gov up to December 2020. The mean change from baseline in the CRP concentrations and its standard deviation (SD) for both intervention and comparison groups were used to calculate the effect size. The summary of the overall effects and heterogeneity was estimated by using the DerSimonian and Laird random effects model. The protocol was registered with PROSPERO (No. CRD42020166053).RESULTS: This study considered 23 articles for systematic review and 19 articles for meta-analysis. The overall effect presented a non-significant effect of soy isoflavones on serum CRP concentrations (WMD = 0.08 mg/L, 95% CI: -0.08, 0.24; p = 0.302) and the overall effect of the combination of soy isoflavones and soy protein indicated non-significant effect in serum levels of CRP (WMD= -0.02 mg/L 95% CI: -0.12, 0.08; p = 0.715).CONCLUSION: Published RCTs did not provide strong evidence regarding beneficial effect of soy isoflavones or the combination of soy isoflavones and soy protein on serum CRP concentration among postmenopausal women.

AB - BACKGROUND: Scientists suggest that soy isoflavones or the combination of soy isoflavones and soy protein may have beneficial effects on inflammation. Thus, the present study aims at conducting a systematic review and meta-analysis on randomized controlled trials (RCTs) in which the effect of soy isoflavones and the combination of soy isoflavones and soy protein on serum concentration of C-reactive protein (CRP) among postmenopausal women is assessed.METHODS AND MATERIALS: A literature searching was done to identify a breadth of related references in PubMed, Scopus, ISI Web of Science, Cochrane Library, and Clinicaltrials.gov up to December 2020. The mean change from baseline in the CRP concentrations and its standard deviation (SD) for both intervention and comparison groups were used to calculate the effect size. The summary of the overall effects and heterogeneity was estimated by using the DerSimonian and Laird random effects model. The protocol was registered with PROSPERO (No. CRD42020166053).RESULTS: This study considered 23 articles for systematic review and 19 articles for meta-analysis. The overall effect presented a non-significant effect of soy isoflavones on serum CRP concentrations (WMD = 0.08 mg/L, 95% CI: -0.08, 0.24; p = 0.302) and the overall effect of the combination of soy isoflavones and soy protein indicated non-significant effect in serum levels of CRP (WMD= -0.02 mg/L 95% CI: -0.12, 0.08; p = 0.715).CONCLUSION: Published RCTs did not provide strong evidence regarding beneficial effect of soy isoflavones or the combination of soy isoflavones and soy protein on serum CRP concentration among postmenopausal women.

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