Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes

Ali A. Al-Mubarak; George Markousis Mavrogenis; Xuanxuan Guo; Marco De Bruyn; Mintu Nath; Simon P.R. Romaine; Niels Grote Beverborg; Karla Arevalo Gomez; Sietske N. Zijlstra; Dirk J. van Veldhuisen; Nilesh J. Samani; Adriaan A. Voors; Peter van der Meer; Nils Bomer

doi:10.1016/j.redox.2024.103046

Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes

Ali A. Al-Mubarak, George Markousis Mavrogenis, Xuanxuan Guo, Marco De Bruyn, Mintu Nath, Simon P.R. Romaine, Niels Grote Beverborg, Karla Arevalo Gomez, Sietske N. Zijlstra, Dirk J. van Veldhuisen, Nilesh J. Samani, Adriaan A. Voors, Peter van der Meer, Nils Bomer^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Background Low selenium concentrations are associated with worse outcomes in heart failure (HF). However, the underlying pathophysiologic mechanisms remain incompletely understood. Therefore, we aimed to contrast serum selenium concentrations to blood biomarker and transcriptomic profiles in patients with HF. Methods Circulating biomarkers, whole blood transcriptomics and serum selenium measurements in a cohort of 2328 patients with HF were utilized. Penalized linear regression and gene expression analysis were used to assess biomarker and transcriptomics profiles, respectively. As a proof-of-principle, potential causal effects of selenium on excreted cytokines concentrations were investigated using human peripheral blood mononuclear cells (PBMCs). Results Mean selenium levels were 60.6 μg/L in Q1 and 122.0 μg/L in Q4. From 356 biomarkers and 20 clinical features, the penalized linear regression model yielded 44 variables with

Original language	English
Article number	103046
Number of pages	10
Journal	Redox Biology
Volume	70
Early online date	31 Jan 2024
DOIs	https://doi.org/10.1016/j.redox.2024.103046
Publication status	Published - 1 Apr 2024

Bibliographical note

Acknowledgements
The authors thank Martin Dokter, Jan Koerts and Karin Koerts-Steijn for their excellent technical assistance.

Data Availability Statement

Data will be made available on request.

Keywords

Selenium
Heart failure
Inflammation
Micronutrients
T cells

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Al-Mubarak_etal_RB_Biomarker_And_Transcriptomics_VoR
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Al-Mubarak, A. A., Markousis Mavrogenis, G., Guo, X., De Bruyn, M., Nath, M., Romaine, S. P. R., Grote Beverborg, N., Arevalo Gomez, K., Zijlstra, S. N., van Veldhuisen, D. J., Samani, N. J., Voors, A. A., van der Meer, P., & Bomer, N. (2024). Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes. Redox Biology, 70, Article 103046. https://doi.org/10.1016/j.redox.2024.103046

Al-Mubarak, AA, Markousis Mavrogenis, G, Guo, X, De Bruyn, M, Nath, M, Romaine, SPR, Grote Beverborg, N, Arevalo Gomez, K, Zijlstra, SN, van Veldhuisen, DJ, Samani, NJ, Voors, AA, van der Meer, P & Bomer, N 2024, 'Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes', Redox Biology, vol. 70, 103046. https://doi.org/10.1016/j.redox.2024.103046

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title = "Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes",

abstract = "Background Low selenium concentrations are associated with worse outcomes in heart failure (HF). However, the underlying pathophysiologic mechanisms remain incompletely understood. Therefore, we aimed to contrast serum selenium concentrations to blood biomarker and transcriptomic profiles in patients with HF. Methods Circulating biomarkers, whole blood transcriptomics and serum selenium measurements in a cohort of 2328 patients with HF were utilized. Penalized linear regression and gene expression analysis were used to assess biomarker and transcriptomics profiles, respectively. As a proof-of-principle, potential causal effects of selenium on excreted cytokines concentrations were investigated using human peripheral blood mononuclear cells (PBMCs). Results Mean selenium levels were 60.6 μg/L in Q1 and 122.0 μg/L in Q4. From 356 biomarkers and 20 clinical features, the penalized linear regression model yielded 44 variables with ",

keywords = "Selenium, Heart failure, Inflammation, Micronutrients, T cells",

author = "Al-Mubarak, {Ali A.} and {Markousis Mavrogenis}, George and Xuanxuan Guo and {De Bruyn}, Marco and Mintu Nath and Romaine, {Simon P.R.} and {Grote Beverborg}, Niels and {Arevalo Gomez}, Karla and Zijlstra, {Sietske N.} and {van Veldhuisen}, {Dirk J.} and Samani, {Nilesh J.} and Voors, {Adriaan A.} and {van der Meer}, Peter and Nils Bomer",

note = "Acknowledgements The authors thank Martin Dokter, Jan Koerts and Karin Koerts-Steijn for their excellent technical assistance.",

year = "2024",

month = apr,

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doi = "10.1016/j.redox.2024.103046",

language = "English",

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T1 - Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes

AU - Al-Mubarak, Ali A.

AU - Markousis Mavrogenis, George

AU - Guo, Xuanxuan

AU - De Bruyn, Marco

AU - Nath, Mintu

AU - Romaine, Simon P.R.

AU - Grote Beverborg, Niels

AU - Arevalo Gomez, Karla

AU - Zijlstra, Sietske N.

AU - van Veldhuisen, Dirk J.

AU - Samani, Nilesh J.

AU - Voors, Adriaan A.

AU - van der Meer, Peter

AU - Bomer, Nils

N1 - Acknowledgements The authors thank Martin Dokter, Jan Koerts and Karin Koerts-Steijn for their excellent technical assistance.

PY - 2024/4/1

Y1 - 2024/4/1

N2 - Background Low selenium concentrations are associated with worse outcomes in heart failure (HF). However, the underlying pathophysiologic mechanisms remain incompletely understood. Therefore, we aimed to contrast serum selenium concentrations to blood biomarker and transcriptomic profiles in patients with HF. Methods Circulating biomarkers, whole blood transcriptomics and serum selenium measurements in a cohort of 2328 patients with HF were utilized. Penalized linear regression and gene expression analysis were used to assess biomarker and transcriptomics profiles, respectively. As a proof-of-principle, potential causal effects of selenium on excreted cytokines concentrations were investigated using human peripheral blood mononuclear cells (PBMCs). Results Mean selenium levels were 60.6 μg/L in Q1 and 122.0 μg/L in Q4. From 356 biomarkers and 20 clinical features, the penalized linear regression model yielded 44 variables with

AB - Background Low selenium concentrations are associated with worse outcomes in heart failure (HF). However, the underlying pathophysiologic mechanisms remain incompletely understood. Therefore, we aimed to contrast serum selenium concentrations to blood biomarker and transcriptomic profiles in patients with HF. Methods Circulating biomarkers, whole blood transcriptomics and serum selenium measurements in a cohort of 2328 patients with HF were utilized. Penalized linear regression and gene expression analysis were used to assess biomarker and transcriptomics profiles, respectively. As a proof-of-principle, potential causal effects of selenium on excreted cytokines concentrations were investigated using human peripheral blood mononuclear cells (PBMCs). Results Mean selenium levels were 60.6 μg/L in Q1 and 122.0 μg/L in Q4. From 356 biomarkers and 20 clinical features, the penalized linear regression model yielded 44 variables with

KW - Selenium

KW - Heart failure

KW - Inflammation

KW - Micronutrients

KW - T cells

U2 - 10.1016/j.redox.2024.103046

DO - 10.1016/j.redox.2024.103046

M3 - Article

C2 - 38295576

SN - 2213-2317

VL - 70

JO - Redox Biology

JF - Redox Biology

M1 - 103046

ER -

Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes

Abstract

Bibliographical note

Data Availability Statement

Keywords

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