Biosynthesis and fate of endocannabinoids

Research output: Chapter in Book/Report/Conference proceedingChapter

34 Citations (Scopus)


Since the discovery of the two cannabinoid receptors, CB1 and CB2, several molecules, commonly defined as endocannabinoids, able to bind to and functionally activate these receptors, have been discovered and characterized. Although the general thought was that the endocannabinoids were mainly derivatives of the n-6 fatty acid arachidonic acid, recent data have shown that also derivatives (ethanolamides) of n-3 fatty acids may be classified as endocannabinoids. Whether the n-3 endocannabinoids follow the same biosynthetic and metabolic routes of the n-6 endocannabinoids is not yet clear and so warrants further investigation. In this review, we describe the primary biosynthetic and metabolic pathways for the two well-established endocannabinoids, anandamide and 2-arachidonoylglycerol.
Original languageEnglish
Title of host publicationEndocanabinoids
Subtitle of host publication Handbook of Experimental Pharmacology
EditorsRoger G. Pertwee
Number of pages10
ISBN (Electronic)978-3-319-20825-1
ISBN (Print)978-3-319-20824-4
Publication statusPublished - 2015

Publication series

NameHandbook of Experimental Pharmacology
ISSN (Electronic)0171-2004


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