Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes

Diana Pinto Prata*, Gerome Breen, Janet Munro, Maggie Sinclair, Sarah Osborne, Tao Li, Robert Kerwin, David St. Clair, David A. Collier

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

16 Citations (Scopus)


Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in the aetiology of schizophrenia play a role in bipolar disorder, and vice versa. In this study we investigated a total of 15 single nucleotide polymorphisms (SNPs), and all possible haplotypes, of genes that have been previously implicated in schizophrenia or bipolar disorder-RGS4, PRODH, COMT and GRK3-in a sample of 213 cases with bipolar affective disorder type 1 and 197 controls from Scotland. We analysed the polymorphisms allele-wise, genotype-wise and, for each gene, haplotype-wise but obtained no result that reached nominal significance (p <0.05) for an association with the disease status. In conclusion, we could not find evidence of association between RGS4, PRODH, COMT and GRK3 genes and bipolar affective disorder 1 in the Scottish population.

Original languageEnglish
Pages (from-to)229-230
Number of pages2
JournalPsychiatric Genetics
Issue number6
Publication statusPublished - Dec 2006


  • bipolar disorder
  • genetic association
  • single nucleotide polymorphisms
  • case control study
  • rgs4
  • comt
  • prodh
  • grk3
  • 22Q11


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