Abstract
Timely and accurate diagnosis of Alzheimer’s disease (AD) in clinical practice remains challenging. PET and CSF biomarkers are the most widely used biomarkers to aid diagnosis in clinical research but present limitations for clinical practice (i.e., cost, accessibility). Emerging blood-based markers have the potential to be accurate, cost-effective, and easily accessible for widespread clinical use, and could facilitate timely diagnosis. The EU/US CTAD Task Force met in May 2022 in a virtual meeting to discuss pathways to implementation of blood-based markers in clinical practice. Specifically, the CTAD Task Force assessed: the state-of-art for blood-based markers, the current use of blood-based markers in clinical trials, the potential use of blood-based markers in clinical practice, the current challenges with blood-based markers, and the next steps needed for broader adoption in clinical practice.
| Original language | English |
|---|---|
| Pages (from-to) | 569-579 |
| Number of pages | 11 |
| Journal | Journal of Prevention of Alzheimer's Disease |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 12 Oct 2022 |
Bibliographical note
Additional information
Task force members: Sandrine Andrieu (Toulouse, France), Phyllis Barkman Ferrell (Indianapolis, USA), Russell Barton (Baltimore, USA), Monika Baudler (Basel, Switzerland), Navia Bradford (Cambridge, USA), Brady Burgess (San Francisco, USA), Brian Campbell (San Francisco, USA), Chris Dague (Malvern, USA), Francesca De Simone (Malvern, USA), Robert Dean (Indianiapolis, USA), Jean-Cosme Dodart (Dallas, USA), Rachelle Doody (Basel, Switzerland), Kristen Eisterhold (Indianapolis, USA), Stephane Epelbaum (Indianapolis, USA), Sven Eriksson (Stockholm, Sweden), Rianne Esquvel (Malvern, USA), Michela Gallagher (Baltimore, USA), Hideki Garren (San Francisco, USA), Sarah Giardina (New York, USA), Ishtar Govia (Kingston, Jamaica), Virginie Gregoire (Indianapolis, USA), Harald Hampel (Nutley, USA), Charles Harrington (Aberdeen, United Kingdom), James Hendrix (Indianapolis, USA), Dave Henley (Titusville, USA), Joseph Herring (North Wales, USA), Helen Hu (Nutley, USA), Farhad Imam (Kirkland, USA), Michael Irizarry (Nutley, USA), Peter Johannsen (Bagsvaerd, Denmark), Paul Kinnon (Solana Beach, USA), Hartmuth Kolb (Titusville, USA), Hisatomo Kowa (Kobe, Japan), Akihiko Koyama (Nutley, USA), Lynn Kramer (Nutley, USA), Lars Lannfelt (Uppsala, Sweden), John Lawson (Malvern, USA), Ferenc Martenyi (San Francisco, USA), Sarah McManus (Titusville, USA), David Miller (Blue Bell, USA), Sonya Miller (Aberdeen, United Kingdom), Richard Mohs (Baltimore, USA), Laura Nisenbaum (New York, USA), Gunilla Osswald (Stockholm, Sweden), Suzanne Ostrowitzki (San Francisco, USA), Lewis Penny (Aberdeen, United Kingdom), Elizabeth Pittampalli (San Francisco, USA), Craig Ritchie (Edinburgh, United Kingdom), Andrew Roche (Dublin, Ireland), Yves Rolland (Toulouse, France), Sharon Rosenzweig-Lipson (Baltimore, USA), Peter Schuler (Langen, Germany), Maria Eugenia Soto Martin (Toulouse), Reisa Sperling (Boston, USA), Erik Stoops (Gent, Belgium), Aishwarya Sukumar (Kirkland, USA), Charlotte Thim Hansen (Bagsvaerd, Denmark), Jacques Touchon (Montpellier, France), Martin Traber (Basel, Switzerland), Gallen Triana-Baltzer (Titusville, USA), Eugeen Vanmechelen (Gent, Belgium), Huijing Yu (Dallas, USA), Wagner Zago (San Francisco, USA), Nancy Zhang (Titusville, USA).
Keywords
- Alzheimer’s disease
- amyloid
- blood biomarkers
- clinical trials
- diagnostic
- neurofilament light
- p-tau
Access to Document
- Angioni_etal_JPAD_BloodBiomarkersFrom_VOR
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