Blood pressure variability and cognitive function: A scoping review

Nur Fazidah Asmuje* (Corresponding Author), Sumaiyah Mat, Phyo Kyaw Myint, Tan Maw Pin* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Purpose of Review
To conduct a scoping review of articles which have evaluated BPV and cognitive function. Articles with keywords, titles or abstracts containing the terms ‘cognitive’ OR ‘cognition’ OR ‘dementia’ AND ‘blood pressure variability’ were identified from CINAHL, Medline, PMC and Web of Science.
Recent Findings
Methods of acquisition and analysis of BPV and cognitive measurements and their relationship were extracted from selected articles. Of 656 studies identified, 53 articles were selected. 25 evaluated long-term (LTBPV), nine mid-term (MTBPV), 12 short-term (STBPV) and nine very-short-term BPV (VSTBPV) with conflicting findings on the relationship between BPV and cognition. Variations existed in devices, period and procedure for acquisition. The studies also utilized a wide range of methods of BPV calculation. Thirteen cognitive assessment tools were used to measure global cognition or domain functions which were influenced by the population of interest.
The interpretation of available studies was hence limited by heterogeneity. There is an urgent need for standardization of BPV assessments to streamline research on BPV and cognition. Future studies should also establish whether BPV could be a potential modifiable risk factor for cognitive decline, as well as a marker for treatment response.
Original languageEnglish
Pages (from-to)375-383
Number of pages9
JournalCurrent Hypertension Reports
Issue number10
Early online date22 Jun 2022
Publication statusPublished - 1 Oct 2022

Bibliographical note

The Malaysian Elders Longitudinal Research (MELoR) study is now part of the Transforming Cognitive Frailty into Later Life Self-Sufficiency (AGELESS) longitudinal cohort study, currently funded by the Ministry of Higher Education Long Term Research Grant Scheme (LRGS/1/2019/UM/01/1). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

Data Availability Statement

Supplementary Information
The online version contains supplementary material available at


  • Aged
  • Cognition
  • Dementia
  • Blood pressure variability
  • Blood pressure


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