Brown adipose tissue transplantation reverses obesity in Ob/Ob mice

Xiaomeng Liu, Siping Wang, Yilin You, Minghui Meng, Zongji Zheng, Meng Dong, Jun Lin, Qianwei Zhao, Chuanhai Zhang, Xiaoxue Yuan, Tao Hu, Lieqin Liu, Yuanyuan Huang, Lei Zhang, Dehua Wang, Jicheng Zhan, Hyuek Jong Lee, John R Speakman, Wanzhu Jin

Research output: Contribution to journalArticlepeer-review

191 Citations (Scopus)


Increasing evidence indicates that brown adipose tissue (BAT) transplantation enhances whole-body energy metabolism in a mouse model of diet-induced obesity. However, it remains unclear whether BAT also has such beneficial effects on genetically obese mice. To address this issue, we transplanted BAT from C57/BL6 mice into the dorsal subcutaneous region of age- and sex-matched leptin deficient Ob/Ob mice. Interestingly, BAT transplantation led to a significant reduction of body weight gain with increased oxygen consumption and decreased total body fat mass, resulting in improvement of insulin resistance and liver steatosis. In addition, BAT transplantation increased the level of circulating adiponectin, whereas it reduced the levels of circulating free T3 and T4, which regulate thyroid hormone sensitivity in peripheral tissues. BAT transplantation also increased 3-adrenergic receptor and fatty acidoxidation relatedgene expressionin subcutaneous and epididymal (EP) white adipose tissue. Accordingly, BAT transplantation increased whole-body thermogenesis. Taken together our results demonstrate that BAT transplantation may reduce obesity and its related diseases by activating endogenous BAT.
Original languageEnglish
Pages (from-to)2461-2469
Number of pages9
Issue number7
Early online date1 Apr 2015
Publication statusPublished - Jul 2015

Bibliographical note

Author contributions include the following: W.J. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. W.Z.J., X.M.L., S.P.W., H.J.L., J.S.R., and Y.L.Y. wrote the manuscript; MHM performed the histology, imaging studies and Western blot; Z.J.Z. and X.M.L. performed the energy metabolism assays and the gene expression analysis; M.D., J.L., Q.W.Z., C.H.Z., X.X.Y., T.H., and L.Q.L. performed the animal surgery and the GTT and ITT studies; and L.Z., D.H.W., and J.C.Z. contributed to the discussion and editing of the manuscript.

This work was supported by the Strategic Priority Research Program (XDB13030000), the Key Research Program (KJZD-EW-L01-03) of the Chinese Academy of Sciences, a grant from the Ministry of Science and Technology of China (2012CBA01301, 2012CB944701), and the National Natural Science Foundation of China (81370951, 31171131) to W.J.


  • Brown Adipose Tissue
  • BAT
  • Transplantation
  • Obesity
  • Mice
  • White adipose tissue
  • WAT


Dive into the research topics of 'Brown adipose tissue transplantation reverses obesity in Ob/Ob mice'. Together they form a unique fingerprint.

Cite this