TY - UNPB
T1 - Butyrate-producing bacteria as probiotic supplement
T2 - beneficial effects on metabolism and modulation of behavior in an obesity mouse model
AU - Garcia-Serrano, Alba M.
AU - Skoug, Cecilia
AU - Axling, Ulrika
AU - Korhonen, Emma Rosmariini
AU - Teixeira, Cristina
AU - Ahrén, Irini Lazou
AU - Mukhopadhya, Indrani
AU - Boteva, Nikoleta
AU - Martin, Jennifer
AU - Scott, Karen
AU - Gratz, Silvia
AU - Stenkula, Karin G.
AU - Holm, Cecilia
AU - Duarte, João M.N.
PY - 2023/11/4
Y1 - 2023/11/4
N2 - Obesity is a risk factor for cardio-metabolic and neurological disease. The contribution of gut microbiota to derangements of the gut-brain axis in the context of obesity has been acknowledged, particularly through physiology modulation by short-chain fatty acids (SCFAs). Thus, probiotic interventions and administration of SCFAs have been employed with the purpose of alleviating symptoms in both metabolic and neurological disease. We have tested the effects of four butyrate-producing bacteria from the Lachnospiraceae family on the development of metabolic syndrome and behavioural alterations in a mouse model of diet-induced obesity. Male mice were fed either a high-fat diet (HFD) or an ingredient-matched control diet for 2 months, and bacteria cultures or culture medium were given by gavage to HFD-fed mice every second day. Assessment of the mice through a battery of metabolic and behaviour tests revealed that one of the administered bacteria affords some degree of protection against the development of obesity and its complications.
AB - Obesity is a risk factor for cardio-metabolic and neurological disease. The contribution of gut microbiota to derangements of the gut-brain axis in the context of obesity has been acknowledged, particularly through physiology modulation by short-chain fatty acids (SCFAs). Thus, probiotic interventions and administration of SCFAs have been employed with the purpose of alleviating symptoms in both metabolic and neurological disease. We have tested the effects of four butyrate-producing bacteria from the Lachnospiraceae family on the development of metabolic syndrome and behavioural alterations in a mouse model of diet-induced obesity. Male mice were fed either a high-fat diet (HFD) or an ingredient-matched control diet for 2 months, and bacteria cultures or culture medium were given by gavage to HFD-fed mice every second day. Assessment of the mice through a battery of metabolic and behaviour tests revealed that one of the administered bacteria affords some degree of protection against the development of obesity and its complications.
UR - https://doi.org/10.1101/2023.11.02.564919
U2 - 10.1101/2023.11.02.564919
DO - 10.1101/2023.11.02.564919
M3 - Preprint
BT - Butyrate-producing bacteria as probiotic supplement
PB - bioRxiv
ER -