Abstract
Fungal infections represent a significant health burden, especially in immunocompromised individuals, yet many of the underlying immunological mechanisms involved in the recognition and control of these pathogens are unclear. The identification of the Toll-like receptors (TLRs) has shed new insights on innate microbial recognition and the initiation of immune responses; however, recent evidence indicates that the 'non-TLR' receptors also have a significant role in these processes, particularly in antifungal immunity. Of interest are members of the C-type lectin-receptor family, including the mannose receptor, dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3)-grabbing non-integrin (DC-SIGN), Dectin-1, Dectin-2 and the collectins. Here, we review the roles of each of these receptors, describing how they contribute to fungal recognition, uptake and killing and also participate in the induction and/or modulation of the host immune response.
Original language | English |
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Pages (from-to) | 27-32 |
Number of pages | 6 |
Journal | Trends in Microbiology |
Volume | 16 |
Issue number | 1 |
Early online date | 21 Dec 2007 |
DOIs | |
Publication status | Published - Jan 2008 |
Keywords
- Animals
- Fungi
- Humans
- Mycoses
- Receptors, Mitogen