C-type lectin receptors of the Dectin-1 cluster: Physiological roles and involvement in disease

Kazuya Tone, Mark H.T. Stappers, Janet A. Willment* (Corresponding Author), Gordon D. Brown* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)
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C-type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin-1 cluster, comprising of seven receptors including MICL, CLEC-2, CLEC-12B, CLEC-9A, MelLec, Dectin-1 and LOX-1. Reflecting the larger CLR family, the Dectin-1 cluster of receptors has a broad range of ligands and functions, but importantly, are involved in numerous pathophysiological processes that regulate health and disease. Indeed, these receptors have been implicated in development, infection, regulation of inflammation, allergy, transplantation tolerance, cancer, cardiovascular disease, arthritis and other autoimmune diseases. In this mini-review, we discuss the latest advancements in elucidating the function(s) of each of the Dectin-1 cluster CLRs, focussing on their physiological roles and involvement in disease
Original languageEnglish
Pages (from-to)2127-2133
Number of pages7
JournalEuropean Journal of Immunology
Issue number12
Early online date13 Nov 2019
Publication statusPublished - Dec 2019

Bibliographical note

Acknowledgements: We apologise to our many colleagues whose valuable work we could not cite due to space constraints. Funding was provided by the Wellcome Trust (102705, 097377), the Medical Research Council Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). KT received a research fellowship from Jikei University School of Medicine.


  • C-type lectin
  • Dectin-1
  • autoimmunity
  • immunity


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