Calcium supplements increase risk of myocardial infarction

The cardiovascular safety of calcium supplements has been revisited with a further meta-analysis,((1)) which concludes that calcium supplementation does not increase coronary heart disease in women, without providing data for men. Their conclusion is at odds with that of our meta-analyses, which reported that calcium increased the risk of myocardial infarction (MI) and possibly stroke in men and women together.((2,3)) There are important differences between approaches to the meta-analyses. In the current paper and previously, the authors suggest that including men and self-reported events may have explained the increased risk of MI from calcium. © 2014 American Society for Bone and Mineral Research.