Can Dietary Patterns Impact Fertility Outcomes?: A Systematic Review and Meta-Analysis

Hugo G Winter; Daniel L Rolnik; Ben W J Mol; Sophia Torkel; Simon Alesi; Aya Mousa; Nahal Habibi; Thais R Silva; Tin Oi Cheung; Chau Thien Tay; Alejandra Quinteros; Jessica A Grieger; Lisa J Moran

doi:10.3390/nu15112589

Can Dietary Patterns Impact Fertility Outcomes? A Systematic Review and Meta-Analysis

Hugo G Winter, Daniel L Rolnik, Ben W J Mol, Sophia Torkel, Simon Alesi, Aya Mousa, Nahal Habibi, Thais R Silva, Tin Oi Cheung, Chau Thien Tay, Alejandra Quinteros, Jessica A Grieger, Lisa J Moran

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

There are conflicting results on the effect of diet on fertility. This study aimed to assess the effect of different dietary patterns on fertility outcomes in populations who conceive spontaneously and those requiring assisted reproductive technology (ART). A systematic search and meta-analysis were performed for studies investigating dietary patterns or whole diets in reproductive aged women requiring ART or conceived naturally. Outcomes were live births, pregnancy rates and infertility rates. In amount of 15,396 studies were screened with 11 eligible studies. Ten different diet patterns were grouped broadly into categories: Mediterranean, Healthy or Unhealthy. For the Mediterranean diet, on excluding high risk-of-bias studies ( n = 3), higher adherence was associated with improved live birth/pregnancy rates in ART [OR 1.91 (95% CI 1.14-3.19, I 2 43%)] ( n = 2). Adherence to various Healthy diets was associated with improved ART outcomes (ProFertility diet and Dutch Dietary Guidelines) and natural conception outcomes (Fertility diet). However, due to the variability in Healthy diets' components, results were not pooled. Studies demonstrated preliminary evidence for the role of dietary patterns or whole diets in improving pregnancy and live birth rates. However, due to heterogeneity across the literature it is currently unclear which diet patterns are associated with improvements in fertility and ART outcomes.

Original language	English
Article number	2589
Number of pages	20
Journal	Nutrients
Volume	15
Issue number	11
DOIs	https://doi.org/10.3390/nu15112589
Publication status	Published - 31 May 2023

Bibliographical note

Author B.M. was funded by a NHMRC Investigator grant (GNT1176437). B.M. reports consultancy, travel support and research funding from Merck.

Data Availability Statement

All data are provided in the journal as Supplementary Material, but additional requirements can be made through contact with the authors.

Keywords

Pregnancy
Female
Humans
Adult
Fertility
Reproductive Techniques, Assisted
Pregnancy Rate
Live Birth
Diet, Mediterranean

Access to Document

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Winter_etal_N_Can_Dietary_Patterns
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Final published version, 42.3 MBLicence: CC BY

Cite this

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title = "Can Dietary Patterns Impact Fertility Outcomes?: A Systematic Review and Meta-Analysis",

abstract = "There are conflicting results on the effect of diet on fertility. This study aimed to assess the effect of different dietary patterns on fertility outcomes in populations who conceive spontaneously and those requiring assisted reproductive technology (ART). A systematic search and meta-analysis were performed for studies investigating dietary patterns or whole diets in reproductive aged women requiring ART or conceived naturally. Outcomes were live births, pregnancy rates and infertility rates. In amount of 15,396 studies were screened with 11 eligible studies. Ten different diet patterns were grouped broadly into categories: Mediterranean, Healthy or Unhealthy. For the Mediterranean diet, on excluding high risk-of-bias studies ( n = 3), higher adherence was associated with improved live birth/pregnancy rates in ART [OR 1.91 (95% CI 1.14-3.19, I 2 43%)] ( n = 2). Adherence to various Healthy diets was associated with improved ART outcomes (ProFertility diet and Dutch Dietary Guidelines) and natural conception outcomes (Fertility diet). However, due to the variability in Healthy diets' components, results were not pooled. Studies demonstrated preliminary evidence for the role of dietary patterns or whole diets in improving pregnancy and live birth rates. However, due to heterogeneity across the literature it is currently unclear which diet patterns are associated with improvements in fertility and ART outcomes. ",

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note = "Author B.M. was funded by a NHMRC Investigator grant (GNT1176437). B.M. reports consultancy, travel support and research funding from Merck.",

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AU - Winter, Hugo G

AU - Rolnik, Daniel L

AU - Mol, Ben W J

AU - Torkel, Sophia

AU - Alesi, Simon

AU - Mousa, Aya

AU - Habibi, Nahal

AU - Silva, Thais R

AU - Oi Cheung, Tin

AU - Thien Tay, Chau

AU - Quinteros, Alejandra

AU - Grieger, Jessica A

AU - Moran, Lisa J

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N2 - There are conflicting results on the effect of diet on fertility. This study aimed to assess the effect of different dietary patterns on fertility outcomes in populations who conceive spontaneously and those requiring assisted reproductive technology (ART). A systematic search and meta-analysis were performed for studies investigating dietary patterns or whole diets in reproductive aged women requiring ART or conceived naturally. Outcomes were live births, pregnancy rates and infertility rates. In amount of 15,396 studies were screened with 11 eligible studies. Ten different diet patterns were grouped broadly into categories: Mediterranean, Healthy or Unhealthy. For the Mediterranean diet, on excluding high risk-of-bias studies ( n = 3), higher adherence was associated with improved live birth/pregnancy rates in ART [OR 1.91 (95% CI 1.14-3.19, I 2 43%)] ( n = 2). Adherence to various Healthy diets was associated with improved ART outcomes (ProFertility diet and Dutch Dietary Guidelines) and natural conception outcomes (Fertility diet). However, due to the variability in Healthy diets' components, results were not pooled. Studies demonstrated preliminary evidence for the role of dietary patterns or whole diets in improving pregnancy and live birth rates. However, due to heterogeneity across the literature it is currently unclear which diet patterns are associated with improvements in fertility and ART outcomes.

AB - There are conflicting results on the effect of diet on fertility. This study aimed to assess the effect of different dietary patterns on fertility outcomes in populations who conceive spontaneously and those requiring assisted reproductive technology (ART). A systematic search and meta-analysis were performed for studies investigating dietary patterns or whole diets in reproductive aged women requiring ART or conceived naturally. Outcomes were live births, pregnancy rates and infertility rates. In amount of 15,396 studies were screened with 11 eligible studies. Ten different diet patterns were grouped broadly into categories: Mediterranean, Healthy or Unhealthy. For the Mediterranean diet, on excluding high risk-of-bias studies ( n = 3), higher adherence was associated with improved live birth/pregnancy rates in ART [OR 1.91 (95% CI 1.14-3.19, I 2 43%)] ( n = 2). Adherence to various Healthy diets was associated with improved ART outcomes (ProFertility diet and Dutch Dietary Guidelines) and natural conception outcomes (Fertility diet). However, due to the variability in Healthy diets' components, results were not pooled. Studies demonstrated preliminary evidence for the role of dietary patterns or whole diets in improving pregnancy and live birth rates. However, due to heterogeneity across the literature it is currently unclear which diet patterns are associated with improvements in fertility and ART outcomes.

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