@article{b0152564a9b64cd88a3d6ef824de6972,
title = "Can We Use Blood Biomarkers as Entry Criteria and for Monitoring Drug Treatment Effects in Clinical Trials?: A Report from the EU/US CTAD Task Force",
abstract = "In randomized clinical trials (RCTs) for Alzheimer{\textquoteright}s Disease (AD), cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers are currently used for the detection and monitoring of AD pathological features. The use of less resource-intensive plasma biomarkers could decrease the burden to study volunteers and limit costs and time for study enrollment. Blood-based markers (BBMs) could thus play an important role in improving the design and the conduct of RCTs on AD. It remains to be determined if the data available on BBMs are strong enough to replace CSF and PET biomarkers as entry criteria and monitoring tools in RCTs.",
keywords = "Alzheimer{\textquoteright}s disease, amyloid, monitoring, randomized clinical trials, screening, tau",
author = "D. Angioni and O. Hansson and Bateman, {R. J.} and C. Rabe and M. Toloue and Braunstein, {J. B.} and S. Agus and Sims, {J. R.} and T. Bittner and Carrillo, {M. C.} and H. Fillit and Masters, {C. L.} and S. Salloway and P. Aisen and M. Weiner and B. Vellas and S. Gauthier and {EU/US/CTAD Task Force} and Susan Abushakra and Mohammad Afshar and John Alam and Alicia Algeciras-Schimnich and Sandrine Andrieu and Clive Ballard and Amos Baruch and Richard Batrla and Monika Baudler and Joanne Bell and Sasha Bozeat and Dawn Brooks and Tricia Brooks and Szofia Bullain and Jan Burmeister and Min Cho and Emily Collins and Gavin Cook and Jeffrey Cummings and Chris Dague and {De Santi}, Susan and Rachelle Doody and Billy Dunn and Michael Egan and Sven Eriksson and Rianne Esquivel and Tom Fagan and Phyllis Ferrell and Michela Gallagher and Gr{\"o}nblad, {Anna Kaija} and Avis Hains and Harald Hampel and Lewis Penny",
year = "2023",
month = sep,
doi = "10.14283/jpad.2023.68",
language = "English",
volume = "10",
pages = "418--425",
journal = "Journal of Prevention of Alzheimer's Disease",
issn = "2274-5807",
publisher = "Springer ",
number = "3",
}
