Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity

Simon Vautier; Rebecca A Drummond; Kong Chen; Graeme I Murray; David Kadosh; Alistair J P Brown; Neil A R Gow; Donna M MacCallum; Jay K Kolls; Gordon D Brown

doi:10.1111/cmi.12388

Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity

Simon Vautier, Rebecca A Drummond, Kong Chen, Graeme I Murray, David Kadosh, Alistair J P Brown, Neil A R Gow, Donna M MacCallum, Jay K Kolls, Gordon D Brown

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Abstract

The ability of Candida albicans to cause disease is associated with its capacity to undergo morphological transition between yeast and filamentous forms, but the role of morphology in colonisation and dissemination from the gastrointestinal (GI) tract remains poorly defined. To explore this, we made use of wild type and morphological mutants of C. albicans in an established model of GI tract colonization, induced following antibiotic-treatment of mice. Our data reveal that GI tract colonization favours the yeast form of C. albicans, that there is constitutive low level systemic dissemination in colonized mice that occurs irrespective of fungal morphology, and that colonization is not controlled by Th17 immunity in otherwise immunocompetent animals. These data provide new insights into the mechanisms of pathogenesis and commensalism of C. albicans, and have implications for our understanding of human disease.

Original language	English
Pages (from-to)	445-450
Number of pages	6
Journal	Cellular Microbiology
Volume	17
Issue number	4
Early online date	25 Nov 2014
DOIs	https://doi.org/10.1111/cmi.12388
Publication status	Published - Apr 2015

Bibliographical note

This article is protected by copyright. All rights reserved.

This work was supported by the Wellcome Trust (086558, 080088, 102705), a
Wellcome Trust Strategic Award (097377) and a studentship from the University of
Aberdeen. D.K. was supported by grant 5R01AI083344 from the National Institute of Allergy and Infectious Diseases and by a Voelcker Young Investigator Award from
the Max and Minnie Tomerlin Voelcker Fund.

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Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity
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Donna MacCallum
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title = "Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity",

abstract = "The ability of Candida albicans to cause disease is associated with its capacity to undergo morphological transition between yeast and filamentous forms, but the role of morphology in colonisation and dissemination from the gastrointestinal (GI) tract remains poorly defined. To explore this, we made use of wild type and morphological mutants of C. albicans in an established model of GI tract colonization, induced following antibiotic-treatment of mice. Our data reveal that GI tract colonization favours the yeast form of C. albicans, that there is constitutive low level systemic dissemination in colonized mice that occurs irrespective of fungal morphology, and that colonization is not controlled by Th17 immunity in otherwise immunocompetent animals. These data provide new insights into the mechanisms of pathogenesis and commensalism of C. albicans, and have implications for our understanding of human disease.",

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note = "This article is protected by copyright. All rights reserved. This work was supported by the Wellcome Trust (086558, 080088, 102705), a Wellcome Trust Strategic Award (097377) and a studentship from the University of Aberdeen. D.K. was supported by grant 5R01AI083344 from the National Institute of Allergy and Infectious Diseases and by a Voelcker Young Investigator Award from the Max and Minnie Tomerlin Voelcker Fund.",

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Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity

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