Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation

A S Douglas, S P Robins, J D Hutchison, R W Porter, A Stewart, D M Reid

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72 Citations (Scopus)


The effect of vitamin supplements on bone metabolism indices in patients with osteoporosis has received scant attention in the literature. Over a 2-week period, vitamin supplements of K and K+D were given to 20 post-menopausal osteoporotic women with previous Colles fractures. Osteoporosis was confirmed by bone mass measurements that demonstrated that broadband ultrasound attenuation (os calcis) was almost as discriminatory as dual energy X-ray absorptiometry (spine and hip) in Colles fracture patients compared with matched controls. Vitamin K corrected the carboxylation defect in osteocalcin and while less marked 4 weeks later, the improvement was still detectable. The result after K+D was similar. The level of carboxylation became the same as in premenopausal women. Total osteocalcin level (bound) osteocalcin. While there was vitamin K correctable undercarboxylation of osteocalcin, simultaneously there was no evidence of undercarboxylation of prothrombin.
Original languageEnglish
Pages (from-to)15-20
Number of pages6
Issue number1
Publication statusPublished - 1995


  • Absorptiometry, Photon
  • Adult
  • Aged
  • Biological Markers
  • Bone Density
  • Colles' Fracture
  • Cross-Over Studies
  • Female
  • Femur
  • Humans
  • Middle Aged
  • Osteocalcin
  • Osteoporosis, Postmenopausal
  • Premenopause
  • Protein Precursors
  • Prothrombin
  • ROC Curve
  • Single-Blind Method
  • Spinal Canal
  • Vitamin D
  • Vitamin K


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